广西医学2017，Vol.39Issue(6)：768-771,4.DOI:10.11675/j.issn.0253-4304.2017.06.04
核糖体S6蛋白激酶4和热休克蛋白90在乳腺癌中的表达情况及其与患者临床病理特征及预后的关系
Expressions of ribosomal protein S6 kinase 4 and heat shock protein 90 in breast cancer and their relationship with clinicopathological features and prognosis of patients
摘要
Abstract
Objective To investigate the expressions of ribosomal protein S6 kinase 4(RSK4) and heat shock protein 90(HSP90) in breast cancer and their relationship with clinicopathological features and prognosis of patients.Methods The expressions of RSK4 and HSP90 proteins in 72 breast cancer tissues and 72 pericarcinoma tissues obtained by surgical incision were detected using immunohistochemistry.The expressions of RSK4 and HSP90 proteins were analyzed in the patients with different clinicopathological features.The survivals were compared between the patients with different RSK4 or HSP90 expression levels.Results The positive expression rate of RSK4 protein in the pericarcinoma tissues was higher than that in the breast cancer tissues(P<0.05).The positive expression rate of HSP90 protein in the breast cancer tissues was higher than that in the pericarcinoma tissues(P<0.05).The RSK4 protein expression negatively correlated with the HSP90 protein expression in the breast cancer tissues(P<0.05).There were significant differences in the positive expression rate of RSK4 protein in the breast cancer tissues between the patients with different differentiation degrees,and with different TNM stages(P<0.05).There were significant differences in the positive expression rate of HSP90 protein in the breast cancer tissues between the patients with different tumor sizes,with or without lymph node metastasis,with different histopathological differentiation degrees,and with different TNM stages(P<0.05).The median survival of the patients with positive expression of RSK4 protein was more than that of the patients with negative expression(71 months vs.54 months;P<0.05),while the median survival of the patients with positive expression of HSP90 protein was less than that of the patients with negative expression(41 months vs.82 months;P<0.05).Conclusion The expressions of RSK4 and HSP90 decrease and increase in breast cancer tissues respectively.RSK4 and HSP90 might affect each other through some channels in breast cancer.关键词
乳腺癌/核糖体S6蛋白激酶4/热休克蛋白90/生存期/临床病理特征Key words
Breast cancer/Ribosomal protein S6 kinase 4/Heat shock protein 90/Survival/Clinicopathological feature分类
医药卫生引用本文复制引用
伍越,杨华伟,杨宁,郇雪洁,姬逸男..核糖体S6蛋白激酶4和热休克蛋白90在乳腺癌中的表达情况及其与患者临床病理特征及预后的关系[J].广西医学,2017,39(6):768-771,4.基金项目
国家自然科学基金(81260394) （81260394）
