海南医学院学报2017，Vol.23Issue(10)：1326-1329,4.DOI:10.13210/j.cnki.jhmu.20170607.008
干扰素调节因子对颈动脉粥样硬化患者斑块性质、T细胞亚群分化的影响
Effect of interferon regulatory factors on the plaque nature and T cell subset differentiation in patients with carotid atherosclerosis
摘要
Abstract
Objective: To study the effect of interferon regulatory factors (IRFs) on the plaque nature and T cell subset differentiation in patients with carotid atherosclerosis.Methods: A total of 68 patients who were diagnosed with carotid artery atherosclerosis in Puren Hospital of Wuhan City between June 2014 and December 2016 were selected as AS group, and 80 healthy volunteers who received physical examination during the same period were selected as control group.Peripheral blood mononuclear cells were collected to detect the expression of IRFs, and serum was collected to detect the levels of cytokines and plaque stability indicators.Results: IRF1 and IRF8 mRNA expression in peripheral blood mononuclear cells of AS group were significantly higher than those of control group while IRF2 and IRF4 mRNA expression were significantly lower than those of control group;serum IFN-γ, IL-2, IL-17, IL-22, MCP-1, ox-LDL, MMP9 and Caspase-3 levels of AS group were significantly higher than those of control group, positively correlated with IRF1 and IRF8 mRNA expression, and negatively correlated with IRF2 and IRF4 mRNA expression;IL-4, IL-10 and TGF-β levels were significantly lower than those of control group, negatively correlated with IRF1 and IRF8 mRNA expression, and positively correlated with RF2 and IRF4 mRNA expression.Conclusions: The high expression of IRF1 and IRF8 and the low expression of IRF2 and IRF4 in patients with carotid atherosclerosis will reduce the plaque stability and affect the Th1/Th2/Th17/Treg differentiation.关键词
干扰素调节因子/颈动脉粥样硬化/T细胞亚群/斑块性质Key words
Interferon regulatory factor/Carotid atherosclerosis/T cell subsets/Plaque nature分类
医药卫生引用本文复制引用
朱晓刚,王丽岳,刘金华,黄继良..干扰素调节因子对颈动脉粥样硬化患者斑块性质、T细胞亚群分化的影响[J].海南医学院学报,2017,23(10):1326-1329,4.基金项目
湖北省自然基金项目(2010CDB8701) （2010CDB8701）
It is supported by Nature Foundation Project of Hubei Province (2010CDB8701). （2010CDB8701）
