海南医学院学报2017，Vol.23Issue(10)：1344-1347,4.DOI:10.13210/j.cnki.jhmu.20170421.009
PCI术后支架内再狭窄患者血清中谷氨酰转移酶及C反应蛋白与血管新生、炎症反应的相关性
Correlation of serum glutamyl transferase (GGT) and C-reactive protein (CRP) with angiogenesis and inflammation in patients with in-stent restenosis after PCI
摘要
Abstract
Objective: To study the correlation of serum glutamyl transferase (GGT) and C-reactive protein (CRP) with angiogenesis and inflammation in patients with in-stent restenosis after PCI.Methods: 240 patients with acute coronary syndrome who received emergency PCI treatment in Cardiovascular Medicine Department of Hanzhong People's Hospital between April 2013 and October 2016 were selected and divided into non-restenosis group and restenosis group after the occurrence of in-stent restenosis within 6 months after PCI was followed up.Before PCI as well as 3 days and 7 days after PCI, serum was collected to determine the levels of GGT, CRP, angiogenesis molecules and inflammatory cytokines.Results: Before PCI as well as 3 days and 7 days after PCI, serum GGT and CRP levels of restenosis group were significantly higher than those of non-restenosis group;7 days after PCI, serum VEGF, Ang-1 and Ang-2 levels of restenosis group were significantly lower than those of non-restenosis group while IL-6 and IL-8 levels were significantly higher than those of non-restenosis group;serum VEGF, Ang-1 and Ang-2 levels of high GGT and CRP level groups were significantly lower than those of low GGT and CRP level groups while IL-6 and IL-8 levels were significantly higher than those of low GGT and CRP level groups.Conclusion: Preoperatively elevated serum GGT and CRP levels can aggravate the inflammation and inhibit the angiogenesis, and have predictive value for the in-stent restenosis after PCI.关键词
经皮冠状动脉介入治疗/支架内再狭窄/谷氨酰转移酶/C反应蛋白Key words
percutaneous coronary intervention/in-stent restenosis/glutamyl transferase/C-reactive protein分类
医药卫生引用本文复制引用
卫娇娜,杨睿海,王永进,杜宏艳..PCI术后支架内再狭窄患者血清中谷氨酰转移酶及C反应蛋白与血管新生、炎症反应的相关性[J].海南医学院学报,2017,23(10):1344-1347,4.基金项目
陕西省科学技术成果(9612011Y0652) （9612011Y0652）
Scientific and technological achievements of Shaanxi province (9612011Y0652) （9612011Y0652）
