海南医学院学报2017，Vol.23Issue(10)：1373-1376,4.DOI:10.13210/j.cnki.jhmu.20170623.001
硫酸镁与硝苯地平联合丹参治疗对子痫前期患者胎盘血流灌注及氧化应激、细胞凋亡的影响
Influence of magnesium sulfate, Nifedipine and Salvia miltiorrhiza treatment on placenta blood perfusion, oxidative stress and apoptosis in preeclampsia patients
摘要
Abstract
Objective: To study the Influence of magnesium sulfate, Nifedipine and Salvia miltiorrhiza treatment on Placenta Blood perfusion, oxidative stress and apoptosis in preeclampsia patients.Methods: A total of 90 cases of pregnant women with preeclampsia were randomly divided into control group (n=45) and control group (n=50).The patients in control group were treated with magnesium sulfate + nifedipine, those in observation group were treated with magnesium sulfate, Nifedipine and Salvia miltiorrhiza treatment, and both were lasted for 7 days.The changes of plasma perfusion parameters, serum oxidative stress indexes and placental apoptotic mRNA expression were compared between two groups.Results: The levels of placental perfusion parameters such as VI, FI and VFI in observation group were higher than those in control group.Serum contents of CAT and GPX inobservation group were higher than those in control group.The levels of ROS and MDA were lower than those in control group, expression of Fas and caspase-9 mRNA in placental tissue were lower than those in control group (P<0.05).The expression of anti-apoptotic Bcl-2 and Survivin mRNA in placental tissue were higher than those in control group (P<0.05).Conclusions: Magnesium sulfate + nifedipine + salvia miltiorrhiza can increase placental perfusion in patients with preeclampsia, reduce systemic oxidative stress and inhibit placental cell apoptosis.关键词
子痫前期/丹参/胎盘血流灌注/氧化应激/细胞凋亡Key words
Preeclampsia/Salvia miltiorrhiza/Placenta Blood perfusion/Oxidative stress/Apoptosis分类
医药卫生引用本文复制引用
黄杏红,邵懿,罗正春..硫酸镁与硝苯地平联合丹参治疗对子痫前期患者胎盘血流灌注及氧化应激、细胞凋亡的影响[J].海南医学院学报,2017,23(10):1373-1376,4.基金项目
2011年黄冈市科技局项目(EK2013D210069001668) （EK2013D210069001668）
It was supported by Science and Technology Bureau project of Huanggang City in 2011 (No.EK2013D210069001668). （No.EK2013D210069001668）
