海南医学院学报2017，Vol.23Issue(10)：1384-1387,4.DOI:10.13210/j.cnki.jhmu.20170511.024
丹参酮联合抗过敏药物对过敏性紫癜患儿血清细胞因子含量及免疫功能的影响
Influence of tanshinone combined with Antiallergic drugs on serum cytokine and immune function in Henoch-Schonlein purpura children
摘要
Abstract
Objective: To study the influence of tanshinone combined with Antiallergic drugs on serum cytokine and immune function in Henoch-Schonlein purpura(HSP) children.Methods: A total of 52 cases of HSP children in Maternal and Child Health Care Hospital of Guangyuan City during April 2013 to July 2016 were chosen as research subject, all children were randomly divided into control group (n=26) and observation group (n=26).Patients in control group were treated with anti-allergic drugs, and those in observation group were treated with tanshinone combined with anti-allergic drugs for two weeks.Before and after treatment, the differences of serum cytokines and immune function between two groups were compared.Results: Before treatment, there were no significant difference between two groups in serum Th17/IL-23 inflammatory axis, renal function indexes, Th1/Th2 immunity, immunoglobulin and complement levels (P>0.05).After treatment, serum contents of IL-23, IL-17 were lower than those in control group, renal function indexes such as Scr, BUN, CysC were lower than those in control group, contents of Th1 cytokines such as IL-2, IFN-γ were higher than those in control group, content of Th2 cytokines such as IL-10, IL-4 and IL-13 were lower than those in control group, contents of IgA, C3, C4 were lower than that those in control group(P<0.05).Conclusions: Tanshinone combined with anti-allergic drugs for the treatment of children with HSP, can help to further inhibit the systemic inflammatory response, reduce renal damage, correct immune dysfunction.关键词
过敏性紫癜/丹参酮/炎症因子/免疫功能Key words
Henoch-Schonlein purpura/Tanshinone/Inflammatory factor/Immune function分类
医药卫生引用本文复制引用
简丽红..丹参酮联合抗过敏药物对过敏性紫癜患儿血清细胞因子含量及免疫功能的影响[J].海南医学院学报,2017,23(10):1384-1387,4.基金项目
2005年四川省科技攻关计划基金项目(2005sz1951) （2005sz1951）
It was supported by Sichuan Province Science and Technology Research Fund Project in 2005 (No.2005sz1951). （No.2005sz1951）
