海南医学院学报2017，Vol.23Issue(10)：1388-1390,1394,4.DOI:10.13210/j.cnki.jhmu.20170511.004
鼻咽癌组织中CD80、CD86表达量与鼻内镜术后复发及肿瘤凋亡、侵袭的相关性
Expression of CD80 and CD86 in nasopharyngeal carcinoma and its correlation with recurrence after endoscopic sinus surgery and invasion and apoptosis
摘要
Abstract
Objective: To study the expression of CD80 and CD86 in nasopharyngeal carcinoma and its correlation with recurrence after endoscopic sinus surgery and invasion and apoptosis.Methods: Nasopharyngeal carcinoma lesions received resection in Nanchong Central Hospital during February 2013-March 2014 were collected and divided into recurrence group and non recurrence group according to recurrence condition 3 years after surgery.Normal nasal mucosa received biopsy during the same period were collected.The expression levels of CD80, CD86 and apoptosis molecules, invasion molecules in lesions were determined.Results: the expression CD80, ARD1, Survivin, Shh, Ptch1, S100A4, Ezrin and N-cadherin in lesion of recurrence group and non recurrence group were significantly higher than the control group, the expression CD80, ARD1, Survivin, Shh, Ptch1, S100A4, Ezrin and N-cadherin in lesion of recurrence group were significantly higher than the non recurrence group.The expression of CD86 in lesion of recurrence group, non recurrence group and control group had no significant difference.The expression of ARD1, Survivin, Shh, Ptch1, S100A4, Ezrin, N-cadherin in CD80 highly expressed nasopharyngeal carcinoma were significantly higher than that of CD80 low expression of nasopharyngeal carcinoma lesions.Conclusions: the high expression of CD80 in nasopharyngeal carcinoma participate recurrence through promoting the proliferation and invasion of tumor cells.关键词
鼻咽癌/CD80/CD86/凋亡/侵袭Key words
Nasopharyngeal carcinoma/CD80/CD86/Apoptosis/Invasion分类
医药卫生引用本文复制引用
吉爽,冯俊,曾晓莉..鼻咽癌组织中CD80、CD86表达量与鼻内镜术后复发及肿瘤凋亡、侵袭的相关性[J].海南医学院学报,2017,23(10):1388-1390,1394,4.基金项目
川北医学院博士科研启动项目(CBY13-QD-08) （CBY13-QD-08）
南充市科技局项目(16YFZJ0021) （16YFZJ0021）
It was supported by Medical College Doctoral Research Project of North Sichuan Province (No.CBY13-QD-08) （No.CBY13-QD-08）
Science and Technology Bureau Project of Nanchong City (No.16YFZJ0021). （No.16YFZJ0021）
