海南医学院学报2017，Vol.23Issue(10)：1395-1397,1401,4.DOI:10.13210/j.cnki.jhmu.20170503.023
幽门螺杆菌L型感染对胃癌组织中增殖、凋亡、侵袭分子表达的影响
Effect of helicobacter pylori L-form infection on proliferation, apoptosis and invasion molecule expression in gastric cancer tissue
摘要
Abstract
Objective: To study the effect of helicobacter pylori L-form infection on proliferation, apoptosis and invasion molecule expression in gastric cancer tissue.Methods: The gastric cancer tissues surgically removed in our hospital between May 2013 and October 2016 were collected and divided into Hp negative, Hp-L negative and Hp-L positive according to the condition of helicobacter pylori infection.The proliferation, apoptosis and invasion gene expression were detected.Results: LOXL2, PCNA, CyclinD1, Rab1A, Bcl-2, Snail, N-cadherin, UHRF1 and AnnexinII mRNA expression in Hp-L-positive gastric cancer tissues were significantly higher than those in Hp-L-negative and Hp-negative gastric cancer tissues while ING5, PTPN13, Beclin1 and Mst1 mRNA expression were significantly lower than those in Hp-L-negative and Hp-negative gastric cancer tissues;LOXL2, PCNA, CyclinD1, Rab1A, Bcl-2, ING5, PTPN13, Beclin1, Mst1, Snail, N-cadherin, UHRF1 and AnnexinII mRNA expression in Hp-L-negative gastric cancer tissues were not different from those in Hp-negative gastric cancer tissues.Conclusions: Helicobacter pylori L-form infection can influence the proliferation, apoptosis and invasion gene expression to promote cell proliferation and invasion, and inhibit cell apoptosis.关键词
胃癌/幽门螺杆菌L型/增殖/凋亡/侵袭Key words
Gastric cancer/Helicobacter pylori L-form/Proliferation/Apoptosis/Invasion分类
医药卫生引用本文复制引用
辛华..幽门螺杆菌L型感染对胃癌组织中增殖、凋亡、侵袭分子表达的影响[J].海南医学院学报,2017,23(10):1395-1397,1401,4.基金项目
湖北潜江市2010科学技术计划项目(2010012) （2010012）
It is supported by 2010 Science and Technology Planning Project of Qianjiang City, Hubei Province (2010012). （2010012）
