海南医学院学报2017，Vol.23Issue(10)：1398-1401,4.DOI:10.13210/j.cnki.jhmu.20170511.010
术前动脉介入化疗对进展期胃癌病灶中癌细胞增殖和侵袭活力的影响
Effects of preoperative intra-arterial interventional chemotherapy on cancer cell proliferation and invasion in advanced gastric cancer
摘要
Abstract
Objective: To study the effect of preoperative intra-arterial interventional chemotherapy on cancer cell proliferation and invasion in advanced gastric cancer.Methods: A total of 134 patients with advanced gastric cancer who received preoperative intra-arterial interventional chemotherapy in AVIC 363 Hospital between May 2014 and September 2016 were selected, and 5-fluorouracil + oxaliplatin + mitomycin solution was used for preoperative intra-arterial interventional chemotherapy.Before and after chemotherapy, gastric cancer lesions were collected respectively, and enzyme linked immunosorbent assay kits were used to detect the expression of pro-proliferation genes C-met, CypA, GOLPH3 and PTP1B, tumor suppressor genes EAF2, ELL, ING5, GKN1 and GKN2 as well as invasion-related genes MMP2, MMP7, MMP11, Snail and Twist.Results: After interventional chemotherapy, C-met, CypA, GOLPH3, PTP1B, MMP2, MMP7, MMP11, Snail and Twist protein expression in gastric cancer lesions were significantly lower than those before interventional chemotherapy while EAF2, ELL, ING5, GKN1 and GKN2 protein expression were significantly higher than those before interventional chemotherapy.Conclusions: Preoperative intra-arterial interventional chemotherapy has a significant inhibitory effect on the proliferation and invasion of cancer cells in advanced gastric cancer.关键词
胃癌/动脉介入化疗/增殖/侵袭/上皮间质转化Key words
Gastric cancer/Intra-arterial interventional chemotherapy/Proliferation/Invasion/Epithelial-mesenchymal transition分类
医药卫生引用本文复制引用
王阳,贺亮..术前动脉介入化疗对进展期胃癌病灶中癌细胞增殖和侵袭活力的影响[J].海南医学院学报,2017,23(10):1398-1401,4.基金项目
四川省卫生厅科研课题(130995) （130995）
It is supported by Science Research Project of Health and Family Planning Commission of Sichuan Province (130995). （130995）
