海南医学院学报2017，Vol.23Issue(10)：1421-1423,3.DOI:10.13210/j.cnki.jhmu.20170615.001
JAK2V617F基因突变与骨髓增殖性肿瘤中细胞增殖及凝血功能的关系
Relationship of JAK2V617F gene mutation with cell proliferation and coagulation function in myeloproliferative neoplasms
摘要
Abstract
Objective: To study the relationship of JAK2V617F gene mutation with cell proliferation and coagulation function in myeloproliferative neoplasms.Methods: Patients who were diagnosed with BCR-ABL-negative myeloproliferative neoplasms in AnYang Area Hospital between June 2014 and August 2016 were selected, JAK2V617F gene mutation was detected, and according to the test results, the patients were divided into mutation-positive group and mutation-negative group.The expression of JAK2/STATs signaling pathway molecules, cell proliferation genes in Bone marrow fluid as well as the coagulation function indexes in peripheral blood were detected.Results: p-JAK2, p-STAT3, p-STAT5, Survivin, C-myc, CyclinD1, ASXL1 protein expression in myeloproliferative neoplasms of mutation-positive group were significantly higher than those of mutation-negative group, and PT and APTT levels in peripheral blood were significantly lower than those of mutation-negative group while TT and FIB levels were not significantly different from those of mutation-negative group.Conclusions: JAK2V617F gene mutation in myeloproliferative neoplasms can promote cell proliferation and cause hypercoagulable state.关键词
骨髓增殖性肿瘤/Jauns激酶/基因突变/增殖Key words
Myeloproliferative neoplasms/Jauns kinase/Gene mutation/Proliferation分类
医药卫生引用本文复制引用
张晓南,孟君霞,栾春来,陈杰甫,唐光,何孜岩,武永强..JAK2V617F基因突变与骨髓增殖性肿瘤中细胞增殖及凝血功能的关系[J].海南医学院学报,2017,23(10):1421-1423,3.基金项目
濮阳市科技攻关(130638) （130638）
It is supported by Project for Science and Technology Development of Puyang City (130638). （130638）
