海南医学院学报2017，Vol.23Issue(10)：1434-1437,4.DOI:10.13210/j.cnki.jhmu.20170406.009
低频重复经颅磁刺激对缺血性脑卒中后抑郁患者血清神经递质、细胞因子的影响
Effect of low-frequency repetitive transcranial magnetic stimulation on serum neurotransmitters and cytokines in patients with ischemic poststroke depression
摘要
Abstract
Objective: To study the effect of low-frequency repetitive transcranial magnetic stimulation on serum neurotransmitters and cytokines in patients with ischemic poststroke depression (PSD).Methods: 68 patients with ischemic poststroke depression who were treated in our hospital between July 2013 and February 2016 were selected as the research subjects and divided into the control group (n=34) who received routine treatment and the observation group (n=34) who received routine treatment + low-frequency repetitive transcranial magnetic stimulation according to the random number table, and the treatment lasted for 4 courses.Immediately after admission and after 4 courses of treatment, the peripheral venous serum was collected from two groups of patients to determine the levels of monoamine neurotransmitters, amino acid neurotransmitters, neurological function indexes and inflammatory cytokines in it.Results: Immediately after admission, the differences in serum levels of monoamine neurotransmitters, amino acid neurotransmitters, neurological function indexes and inflammatory cytokines were not statistically significant between the two groups of patients (P>0.05).After 4 courses of treatment, serum monoamine neurotransmitters NE, 5-HT and DA levels of observation group were higher than those of control group;serum amino acid neurotransmitters Glu and Asp levels were lower than those of control group while Gly and GABA levels were higher than those of control group;serum neurological function index BDNF level was higher than that of control group while NSE level was lower than that of control group;serum inflammatory cytokines IL-1β, IL-2, IL-6 and TNF-α levels were lower than those of control group (P<0.05).Conclusion: Low-frequency repetitive transcranial magnetic stimulation can adjust the excitatory/inhibitory neurotransmitter levels, stimulate the monoamine neurotransmitter secretion, optimize the neurological function and reduce the systemic inflammatory response in patients with ischemic poststroke depression.关键词
缺血性脑卒中后抑郁/低频重复经颅磁刺激/神经递质/细胞因子Key words
Ischemic poststroke depression/Low-frequency repetitive transcranial magnetic stimulation/Neurotransmitter/Cytokines分类
医药卫生引用本文复制引用
杨柳,刘玉山,吴宁渤,刘宏丽..低频重复经颅磁刺激对缺血性脑卒中后抑郁患者血清神经递质、细胞因子的影响[J].海南医学院学报,2017,23(10):1434-1437,4.基金项目
秦皇岛市科技支撑计划项目(201401A196 （）
It was funded by Science and Technology Support Project of Qinhuangdao City (No.201401A196). （No.201401A196）
