河北医学2017，Vol.23Issue(6)：902-904,3.DOI:10.3969/j.issn.1006-6233.2017.06.07
大剂量阿托伐他汀对不稳定性心绞痛患者冠脉狭窄程度hs-CRP的影响
High Dose Atorvastatin on Coronary Artery Stenosis and hs-CRP in Patients with Unstable Angina Pectoris
卢清玉 1常宇锋 1刘庚1
作者信息
- 1. (北京市海淀医院/北京大学第三医院海淀院区), 北京 海淀区 100080
- 折叠
摘要
Abstract
Objective:To explore the influence of high-dose atorvastatin on the degree of coronary artery stenosis, hs-CRP for unstable angina (UA) patients.Methods: 145 cases of UA patients admitted in our hospital from July 2013 to July 2015 were choosen as the research object, and those patients were randomly divided into two groups by the random number table method: the control group and study group.Both groups were given aspirin, metoprolol, and isosorbide dinitrate tablets as the conventional treatment.In the meantime, the control group (70 cases) was given Atorvastatin 10mg per day;while the study group (75 cases) was given atorvastatin 40mg per day.Before and after treatment of 7d, 15d, 30d treatment, high sensitivity C reactive protein in the patients of the two groups (hs-CRP) and a-lipoprotein level were recorded.And the pearson correlation analysis on the relationship between hs-CRP and the degree of coronary artery stenosis were analyzed.Results: The hs-CRP level of the study group were all significantly lower than that of the control group after 7-day and 15-day''s treatment (P<0.05);the vascular embolization rate of the study group was significantly lower than that of the control group after 15-day and 30-day''s treatment (P<0.05).And Pearson correlation analysis revealed that the serum hs-CRP were all significantly associated with the degree of coronary artery stenosis (r=0.264, P=0.032;r=0.425, P=0.014).Conclusion:Early large-dose application of atorvastatin can significantly reduce the level of hs-CRP and vascular embolization rate for UA patients, and the level of hs-CRP are positively correlated with the degree of coronary artery stenosis.关键词
阿托伐他汀/不稳定型心绞痛/超敏C反应蛋白Key words
Atorvastatin/Unstable angina/hs-CRP引用本文复制引用
卢清玉,常宇锋,刘庚..大剂量阿托伐他汀对不稳定性心绞痛患者冠脉狭窄程度hs-CRP的影响[J].河北医学,2017,23(6):902-904,3.
