中医药导报2017，Vol.23Issue(11)：38-40,3.
多药效学指标评价心脉神组方的提取工艺
Applying Multiple Pharmacodynamics Index for Evaluation of Extraction Process of Xinmaisheng (心脉神组方)
摘要
Abstract
Objective:To evaluate the extraction processes of Xinmaisheng by multiple pharmacodynamics index evaluation.Methods:The atmospheric hypoxia model of mice were applied to compared the effects on survival time among different extraction;The arrhythmia model of mice were applied to compared the effects on ventricular fibrillation among different extraction;Hemorheology model of rats were established to evaluate effects of different extraction processes.Blood stasis model induced by adrenaline and ice water were applied to compared the effects on hemorheology among different extraction.Results:The survival time of the mice in all processes (water extraction process group,alcohol extraction process group and water extraction alcohol precipitation process group) were all significantly prolonged for different dosages.The high dosage group of alcohol extraction process can reduce the arrhythmia of mice induced by chloroform.Different dosages of the three extraction process could affect Hemorheology of rats induced by epinephrine and ice water.Conclusion:All the three extraction processes showed different effect in these animal experiments.关键词
心脉神/提取工艺/多药效学指标评价/小鼠/大鼠Key words
Xinmaisheng/extraction process/multiple pharmacodynamics index evaluation/mice/rat分类
医药卫生引用本文复制引用
雷健,胡雪莲,张恩娟..多药效学指标评价心脉神组方的提取工艺[J].中医药导报,2017,23(11):38-40,3.基金项目
重庆市高校优秀成果转化资助项目(编号:KJZH14110) （编号:KJZH14110）
重庆市卫生局中医药科技项目(编号:2010-1-12) （编号:2010-1-12）
