激光生物学报2017，Vol.26Issue(2)：138-142,5.DOI:10.3969/j.issn.1007-7146.2017.02.008
Becn1通过线粒体凋亡途径参与调控肺癌细胞的凋亡过程
Becn1 Regulates Cell Apoptosis of Lung Cancer by Mitochondrial Apoptosis Pathway
摘要
Abstract
Autophagy related gene Becn1 is low expression in many tumors,such as lung cancer,which can inhibit the occurrence and development of tumors.At present,it's reported that Becn1 can regulate the occurrence and development of lung cancer by autophagic pathway and autophagy is closely related to apoptosis,but the mechanism has not been fully elucidated.In this study,PC9 and A549 lung cancer cell lines were selected and established the models with high Becn1 expression.The co-immunoprecipitation and GFP-BECLIN1 and DsRed-Mit fluorescence co-localization experiments were used to confirm that Becn1 could regulate cell apoptosis in lung cancer through mitochondrial pathway.关键词
肺癌/Becn1/自噬/线粒体凋亡Key words
lung cancer/Becn1/autophagy/mitochondrial apoptosis分类
生物科学引用本文复制引用
王远航,夏盛源,张岚..Becn1通过线粒体凋亡途径参与调控肺癌细胞的凋亡过程[J].激光生物学报,2017,26(2):138-142,5.基金项目
国家自然科学基金项目(81102159) （81102159）
广东省自然科学基金项目(2016A030313567) （2016A030313567）
广州市教育局广州市属高校"羊城学者"科研项目(12A010D) （12A010D）
广州市科技计划项目(201607010035) （201607010035）
