临床口腔医学杂志2017，Vol.33Issue(6)：340-342,3.DOI:10.3969/j.issn.1003-1634.2017.06.007
干细胞基因OCT-4,SOX2在口腔癌及癌旁组织中表达情况的研究
The expression of multi-potent gene OCT-4 and SOX2 in or around oral cancer tissue
赵晖 1陈卫民1
作者信息
- 1. 华中科技大学同济医学院附属同济医院口腔医学中心 湖北 武汉 430030
- 折叠
摘要
Abstract
Objective:To detect the significant difference in the expression of stem cell gene OCT-4,SOX2 in and around oral cancer tissue.Methods:Six tumor specimens were obtained from surgical department of oral and maxillofacial which were diagnosed as oral cancer.Immunofluorescence and RT-PCR assay were applied to test the association of multi-potent gene to the development of oral cancer,combining with the differentiated level.Results:The result of RT-PCR and positive cell ratio on immunofluorescence in six tumor patients revealed that the expression of stem cell gene were increased in cancer tissue compared with the cancer associate tissue.Conclusion:The overexpression of stem cell gene OCT-4,SOX2 is tightly relating to the development of oral cancer.关键词
口腔癌/肿瘤干细胞/OCT-4/SOX2Key words
Oral cancer/Cancer stem cell/OCT-4/SOX2分类
生物科学引用本文复制引用
赵晖,陈卫民..干细胞基因OCT-4,SOX2在口腔癌及癌旁组织中表达情况的研究[J].临床口腔医学杂志,2017,33(6):340-342,3.
