临床眼科杂志2017，Vol.25Issue(3)：193-196,4.DOI:10.3969/j.issn.1006-8422.2017.03.001
他克莫司滴眼液预防高危角膜移植免疫排斥反应的研究
The immunosuppressive activity of tacrolimus eye drops in high-risk corneal transplantation
摘要
Abstract
Objective To assess the immunosuppressive activity of 0.1% tacrolimus eye drops in high-risk corneal transplantation.Methods A retrospective study.48 patients who received successful high-risk corneal transplantation in Shandong Eye Hospital were selected from 2013 to 2015.They were divided into tacrolimus group (23 patients, 25 eyes) and cyclosporine (25 patients, 25 eyes).All patients were scored for rejection risk before surgery.We used rejection index (RI) to determine whether the immune rejection had occurred.We considered immune rejection occurred when RI≥5.All patients were followed up for 1 year.We compared rate of rejection.Results The pre-operative rejection risk score was not statistically different between tacrolimus group and cyclosporine group (t=0.65,P=0.52).10 patients (10 eyes) in cyclosporine group developed immune rejection (rate 40.0%).3 patients (3 eyes) in tacrolimus group developed immune rejection (rate 12.0%).The rejection rate was significantly lower in tacrolimus group than in cyclosporine group (χ2=5.09, P<0.05).Conclusions Topical application of 0.1% tacrolimus eye drops suppressed graft rejection in high risk corneal transplantation.关键词
他克莫司/高危角膜移植/免疫排斥/环孢素Key words
Tacrolimus eye drops/High-risk corneal transplantation/Grafts rejection/Cyclosporin A eye drops引用本文复制引用
张鲁天,李素霞,张娜,边江,史伟云..他克莫司滴眼液预防高危角膜移植免疫排斥反应的研究[J].临床眼科杂志,2017,25(3):193-196,4.基金项目
国家自然科学基金(81500702,81530027) （81500702,81530027）
泰山学者攀登计划(tspd20150215) （tspd20150215）
