临床与实验病理学杂志2017，Vol.33Issue(4)：355-359,5.DOI:10.13315/j.cnki.cjcep.2017.04.001
食管鳞状细胞癌中PD-L1的表达及其预后意义
Expression of PD-L1 and its prognostic role in patients with esophageal squamous cell carcinoma
摘要
Abstract
Purpose To analyze the correlations between PD-L1 expression and clinicopathological factors and their prognostic values in esophageal squamous cell carcinoma (ESCC) patients.Methods PD-L1 expression in the primary tumors from 253 patients with ESCC was evaluated using tissue microarray and immunohistochemistry (IHC).PD-L1 positivity was defined as positive staining of 1％ and 5％ tumor cells.Survival curves were constructed by using the Kaplan-Meier method.Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables.Results Overall,tumoral PD-L1 expression was potentially associated with favorable DFS and OS.When the patients were stratified into stage Ⅰ + Ⅱ (60.9％,154/253) and stage Ⅲ + Ⅳa (39.1％,99/253),the prognostic role was not consistent.In patients with stage Ⅰ + Ⅱ disease,tumoral PD-L1 expression was associated with better DFS and OS upon multivariate analysis (1％ as the cutoff:P =0.046 and 0.021,5％ as the cutoff:P=0.011 and0.004).However,PD-L1 expression was not correlated with prognosis in patients with stage Ⅲ + Ⅳa disease (1％ as the cutoff:P =0.586 and 0.682,5％ as the cutoff:P =0.807 and 0.620).Conclusion The prognostic role of tumoral PDL expression is variable in different stages of ESCC,and tumoral PDL expression is an independent favorable predictor in ESCC patients with Stage Ⅰ-Ⅱ disease,but not in stage Ⅲ-Ⅳa or lymph node metastasis.关键词
食管肿瘤/鳞状细胞癌/PD-L1/临床分期/预后标志物Key words
esophageal neoplasms/squamous cell carcinoma/PD-L1 expression/clinical stage/prognostic marker分类
医药卫生引用本文复制引用
刘亚岚,蒋冬先,侯英勇,徐一凡,宿杰阿克苏,曾海英,高峰,张小垒,徐晨..食管鳞状细胞癌中PD-L1的表达及其预后意义[J].临床与实验病理学杂志,2017,33(4):355-359,5.基金项目
上海市卫生计生系统重点薄弱学科建设基金(2015ZB0201) （2015ZB0201）
