临床与实验病理学杂志2017，Vol.33Issue(4)：365-369,5.DOI:10.13315/j.cnki.cjcep.2017.04.003
胆管细胞癌中CtBP1、Zeb1、Zeb2与E-cadherin蛋白的表达及临床意义
Expression of CtBP1, Zeb1, Zeb2 and E-cadherin in cholangiocarcinoma and their clinical significance
摘要
Abstract
Purpose To investigate the expression of transcriptional suppressor CtBP1,Zeb1,Zeb2 and their target gene E-cadherin,and their significance in cholangiocarcinoma.Methods The expression of CtBP1,Zeb1,Zeb2 and E-cadherin proteins in cholangiocarcinoma and the paired non-neoplastic tissue array were detected by the immunohistohemical staining.Results The positive rates of CtBP1 expression in cholangiocarcinoma and the paired non-neoplastic tissue were 44.44％ and 17.86％,these of Zeb2 were 34.92％ and 10.71％,and these of E-cadherin were 50.79％ and 100％,respectively.The differences between the groups were statistically significant (all P ＜ 0.05).There was only one case with expression of Zeb1 in cholangiocarcinoma,but no expression in the paired non-neoplastic tissue.CtBP1 was correlated with the degree of differentiation of cholangiocarcinoma (P ＜ 0.05).Ecadherin was related to the differentiation degree,and distant metastasis of cholangiocarcinoma (all P ＜ 0.05).The E-cadherin expression was negatively correlated with CtBP1 and Zeb2 (r =-0.034,-0.029,all P ＜ 0.05).The Zeb2 expression was positively correlated with CtBP1 (r =0.228,P =0.005).Conclusion CtBP1,Zeb2 and E-cadherin express abnormally in cholangiocarcinoma.CtBP1,Zeb2 may be involved in the regulation of E-cadherin expression.Joint detection of CtBP1 and Ecadherin is expected to be a reference index to evaluate the malignant biological behavior of cholangiocarcinoma.关键词
肝肿瘤/胆管细胞癌/Zeb1/Zeb2/羧基末端结合蛋白1/E-cadherinKey words
liver neoplasms/cholangiocarcinoma/Zeb1/Zeb2/CtBP1/E-cadherin分类
医药卫生引用本文复制引用
胡洁,边立会,王晓玉,杨月丽,张小玲,肖胜军..胆管细胞癌中CtBP1、Zeb1、Zeb2与E-cadherin蛋白的表达及临床意义[J].临床与实验病理学杂志,2017,33(4):365-369,5.基金项目
国家自然科学基金(81660485)、广西壮族自治区和计划生育委员会资助课题(Z2015404) （81660485）
