结直肠癌原发灶与肝转移灶中KRAS、PIK3CA基因突变的一致性分析OA北大核心CSCDCSTPCD
Correlation of KRAS and PIK3CA gene status between primary tumors and paired metastases in colorectal cancer
目的 探讨结直肠癌原发灶及相应肝转移灶中KRAS、PIK3CA基因突变及临床意义.方法 采用实时荧光定量PCR法检测58例结直肠癌原发灶癌组织及相应肝转移灶组织中KRAS、PIK3CA基因突变情况.结果 结直肠癌原发灶与肝转移灶中KRAS基因的突变率分别为31.03％ (18/58)、25.86％(15/58),最常见的突变位点为G12D;PIK3 CA基因的突变率分别为8.62％(5/58)、10.34％ (6/58),最常见的突变位点为E54…查看全部>>
Purpose To investigate the mutation status of KRAS and PIK3CA gene in colorectal cancer (CRC) primary lesions and corresponding liver metastasis and its clinical significance.Methods The gene mutations of KRAS and PIK3CA were detected in 58 cases of primary lesions of CRC and corresponding liver metastasis tissue by real-time PCR.Results The mutation rates of KRAS were 31.03％ (18/58) and 25.86％ (15/58) in primary lesions of CRC and corresponding liver metast…查看全部>>
韩丹丹;郗彦凤;白文启;高宁;王丽丽
山西医科大学研究生院,太原030001山西省肿瘤医院病理科,太原030013山西省肿瘤医院病理科,太原030013山西省肿瘤医院病理科,太原030013山西省汾阳医院内分泌科,汾阳032200
医药卫生
结直肠肿瘤KRASPIK3CA预后
colorectal neoplasmsKRASPIK3CAprognosis
《临床与实验病理学杂志》 2017 (4)
369-374,6
山西省科技厅重点研发项目(201603D321049)、山西省卫生和计划生育委员会科研课题(2014052)
评论