临床与实验病理学杂志2017，Vol.33Issue(4)：388-392,5.DOI:10.13315/j.cnki.cjcep.2017.04.008
外周细胞淋巴瘤中TET2和DNMT3A的表达及意义
Expression of TET2 and DNMT3A in peripheral T cell lymphoma and their significance
孙孟琦 1王丽丽 2冉雯雯 2李宏 2邢晓明2
作者信息
- 1. 青岛大学基础医学院病理学教研室,青岛266071
- 2. 青岛大学附属医院病理科,青岛266003
- 折叠
摘要
Abstract
Purpose To investigate the expression of TET2 and DNMT3A in patients with peripheral T cell lymphoma (PTCL) and the relationship to immunophenotypes of PTCL.Methods Using a panel of immunohistochemical markers (CD3,CD4,CD10,BCL-6,CXCL-13,CD30,ALK),all cases of PTCLs were further divided into four groups,including angioimmunoblastic T cell lymphoma (AITL),peripheral T cell lymphoma,not otherwise specified (PTCL-NOS),anaplastic lymphoma kinase negative anaplastic large cell lymphoma (ALK-ALCL) and anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK + ALCL).The expression of TET2 and DNMT3A in 89 cases of PTCL was detected by immunohistochemical analysis.Results 89 cases were divide into four subtypes,AITL (36/89),PTCL-NOS (26/89),ALKALCL (18/89),and ALK + ALCL (9/89).Immunohistochemistry staining revealed higher cytoplasmic expression of TET2 and DNMT3A in AITL than that of in PTCL-NOS and ALCL (P ＜ 0.05).And the nuclear expression of DNMT3A in patients with AITL was higher than that of PTCL-NOS and ALCL (P ＜ 0.05).The cytoplasmic expression of TET2 was positively related with both cytoplasmic and nuclear expression of DNMT3A in patients with AITL (P ＜ 0.05).Conclusion TET2 combined with DNMT3A could be used as markers in AITL diagnosis,which could provide new strategy for AITL diagnosis.关键词
淋巴瘤/外周T细胞淋巴瘤/TET2/DNMT3A/免疫组织化学Key words
lymphoma/peripheral T cell lymphoma/TET2/DNMT3A/immunohistochemistry分类
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孙孟琦,王丽丽,冉雯雯,李宏,邢晓明..外周细胞淋巴瘤中TET2和DNMT3A的表达及意义[J].临床与实验病理学杂志,2017,33(4):388-392,5.
