临床与实验病理学杂志2017，Vol.33Issue(4)：398-402,5.DOI:10.13315/j.cnki.cjcep.2017.04.010
膀胱尿路上皮癌中DAB2IP和β-catenin的表达及临床意义
Expression of DAB2IP and β-catenin in bladder urothelial carcinoma and their clinical significance
摘要
Abstract
Purpose To investigate the clinical utility of DAB2IP (DOC-2/DAB2 interactive protein)and β-catenin expression in bladder urothelial carcinoma (BUC).Methods The expression of DAB2IP and β-catenin was detected in 104 BUC cases and 40 peritumorial tissues using EnVision two-step immunohistochemical method,and the association with BUC clinicopathological parameters was analyzed.Results The expression of DAB2IP in BUC was significantly less than that of peritumorial normal tissues,and the expression of β-catenin in BUS was significantly higher than that of peritumorial normal tissues (P ＜ 0.05).DAB2IP expression and histologic grading,clinical pathologic staging and 5 years survival rate had statistical significance (P ＜ 0.05).No statistical significance with gender,age,tumor diameter and in patients with incipient/recurrence.β-catenin expression and age,histologic grading,clinical pathologic staging,tumor diameter and 5 years survival rate have statistical significance (P ＜ 0.05).No statistical significance correlated with gender and in patients with incipient/ recurrence,DAB2IP and β-catenin expression in BUC are negatively correlated (P ＜ 0.05).Conclusion In bladder urothelial carcinoma,down-regulation of DAB2IP and up-regulation of β-catenin,are in a negative correlation.Abnormal expression of DAB2IP and β-catenin is correlated with histologic grading,clinical pathologic staging and prognosis.关键词
膀胱肿瘤/尿路上皮癌/DAB2IP/β-catenin/免疫组织化学Key words
bladder neoplasms/urothelial carcinoma/DAB2IP/β-catenin/immunohistochemistry分类
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郑林峰,倪型灏,程国平,杨世峰..膀胱尿路上皮癌中DAB2IP和β-catenin的表达及临床意义[J].临床与实验病理学杂志,2017,33(4):398-402,5.
