临床与实验病理学杂志2017，Vol.33Issue(5)：477-481,5.DOI:10.13315/j.cnki.cjcep.2017.05.002
乳腺癌组织中SOX4、EZH2的表达及临床意义
Expression of SOX4 and EZH2 in breast cancer and their clinicopathologic significance
摘要
Abstract
Purpose To explore the expression of two epithelial-mesenchymal transition (EMT) regulators,Sry-related high mobility group box 4 (SOX4) and enhancer of zeste homolog 2 (EZH2),in breast cancer tissues and their clinicopathologic significances.Methods The expression of SOX4 and EZH2 was detected by immunohistochemistry of EnVision twostep in paraffin-embedded tissue sections from 241 cases of breast cancer and 126 cases of paracancerous breast tissues.The relationship between their expression and clinicopathologic characteristics was statistically analyzed,and their correlation was also analyzed.Results In breast cancer tissues and paracancerous breast tissues,the high expression rates of SOX4 were 82.2％ and 57.1％ respectively,while the high expression rates of EZH2 were 80.1％ and 47.6％ respectively.Their expression in breast cancer tissues was higher than that in paracancerous breast tissues (P ＜ 0.05).High SOX4 expression was correlated with lymph node metastasis,high TNM stage,and overexpression of HER-2 (P ＜ 0.05),while high EZH2 expression was correlated with high histological grade,lymph node metastasis,ER negativity,EGFR positivity and high poliferation index of Ki67 (P ＜ 0.05).There was a positive correlation between SOX4 and EZH2 expression in breast cancer tissues (rs =0.256,P ＜0.001).Conclusion EMT regulators SOX4 and EZH2 might be responsible for the metastasis of breast cancer,which are upregulated in breast cancer tissues.They may act as potential biomarkers to predict the metastasis of breast cancer.关键词
乳腺肿瘤/上皮-间质转化/SOX4/EZH2/免疫组织化学Key words
breast neoplasm/epithelial-mesenchymal transition/SOX4/EZH2/immunohistochemistry分类
医药卫生引用本文复制引用
甘艺,吴正升,吴强..乳腺癌组织中SOX4、EZH2的表达及临床意义[J].临床与实验病理学杂志,2017,33(5):477-481,5.基金项目
国家自然科学基金(81372476、81472493) （81372476、81472493）
