临床与实验病理学杂志2017，Vol.33Issue(5)：520-524,5.DOI:10.13315/j.cnki.cjcep.2017.05.011
混合细胞型肝癌的临床病理分析
Clinicopathological analyses of combined hepatocellular carcinoma and cholangio carcinoma
余立权 1万阳 2陈江明 1余忠山 1李培坤 1谢胜学1
作者信息
- 1. 安徽医科大学第二附属医院普外科,合肥230601
- 2. 安徽医科大学第二附属医院病理科,合肥230601
- 折叠
摘要
Abstract
Purpose To investigate the clinicopathological characteristics and treatment of combined hepatocellular carcinoma-cholangio carcinoma (cHCC-CC).Methods 24 cases of cHCC-CC were collected.The clinical pathological characteristics,imaging,immunophenotyping and clinical features were retrospectively analyzed and reviewed the literature.Results There were 18 males and 6 females in 24 cases of cHCC-CC.The age ranged from 36 to 68 years (mean age was 54.38).Tumour location:right hepatic lobe in 15 cases,left hepatic lobe in 6 cases,both left lobe and right hepatic lobe in 1 case,hepatic caudate and left lateral lobe in 1 case,diffuse nodular liver tumors in 1 case.Grossly,the texture and color of tumor was related to the composition of tumor.Microscopically,classic cHCC-CC had two areas composed of hepatocellular carcinoma area and cholangiocar cinoma area of mixed distribution or migration distribution.3 cases were cHCC-CC with stem cell properties (cholangiolocellular carcinoma type,CLC type).Immunohistochemical staining revealed that HCC like area mainly expressed CD10,CK8,Hepatocyte and CD10,cHCC-CC area expressed CK7 and EMA.CLC type expressed the immunophenotypic features of intermediate type of HCC.Conclusion The clinical manifestations of cHCC-CC are not specific,the preoperative diagnosis is difficult,and it should be combined with pathological characteristics,imaging features and immunophenotype diagnosis.关键词
肝肿瘤/混合型肝癌/临床病理特征/免疫组织化学Key words
hepatic neoplasm/combined hepatocellular carcinoma-cholangio carcinoma/clinicopathologitcal characteristics/immunohistocbemistry分类
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余立权,万阳,陈江明,余忠山,李培坤,谢胜学..混合细胞型肝癌的临床病理分析[J].临床与实验病理学杂志,2017,33(5):520-524,5.
