临床与实验病理学杂志2017，Vol.33Issue(5)：539-543,5.DOI:10.13315/j.cnki.cjcep.2017.05.015
三阴型乳腺癌中CD47的表达及其临床意义
Expression and clinical significance of CD47 in triple negative breast carcinoma
张帆 1张伟 1焦南林 1刘霞 1曹明 2徐国祥 1张伟璇1
作者信息
- 1. 皖南医学院弋矶山医院临床病理科,芜湖 241001
- 2. 芜湖市第一人民医院病理科 241000
- 折叠
摘要
Abstract
Purpose To explore the expression and clinical significance of CD47 in triple negative breast carcinoma (TNBC),and to analyze the relationship between CD47 expression and clinicopathologic features.Methods Immunohistochemical of Bond Polymer Refine Detection staining was performed on tissue array.It contains 185 cases of TNBC and 35 cases of non triple negative breast carcinoma (NTNBC).Then we observed the expression of CD47 in TNBC,and analyzed the relationship between the expression of CD47 and various clinical pathological characteristics.Results The expression of CD47 in tumor cells of TNBC was higher than that in NTNBC,and the difference was statistically significant (P ＜ 0.05).The CD47 expression rate in TNBC tumors was 52.3％.It was closely related to clinical stage (P ＜ 0.05),lymph node metastasis and distant metastasis (P ＜ 0.05) and vascular invasion (P ＜ 0.05).Conclusion The expression of CD47 is correlated with the clinical stage,lymph node metastasis,distant metastasis and vascular invasion of TNBC.CD47 can be used as a prognostic indicator and a potential target for immune therapy.关键词
乳腺肿瘤/三阴型乳腺癌/CD47/免疫组织化学/靶向治疗Key words
breast neoplasm/triple negative breast carcinoma/CD47/immunohistochemistry/targeted therapy分类
医药卫生引用本文复制引用
张帆,张伟,焦南林,刘霞,曹明,徐国祥,张伟璇..三阴型乳腺癌中CD47的表达及其临床意义[J].临床与实验病理学杂志,2017,33(5):539-543,5.
