中国临床保健杂志2017，Vol.20Issue(4)：404-407,4.DOI:10.3969/J.issn.1672-6790.2017.04.020
超声检查甲状腺功能亢进症伴有甲状腺结节患者的临床特点和131碘治疗效果分析
Analysis of clinical features and efficacy of 131I treatment in hyperthyroid patients with thyroid nodules diagnosed by ultrasonography
摘要
Abstract
Objective To evaluate clinical features and efficacy of 131I therapy in hyperthyroid patients with thyroid nodule diagnosed by ultrasonography.Methods Retrospective study was used in hyperthyroid patients individually treated by 131I and the patients were divided into nodule group and non-nodule group according to thyroid nodule diagnosed by ultrasonography.The clinical features and the efficacy of 131I therapy of two group patients were analyzed.Results 75 patients with hyperthyroidism had been recruited.Non-nodule group consisted of 43 patients with Graves' disease.32 hyperthyroid patients in nodule group,including 16 patients with small nodule (length-diameter of the largest thyroid nodule ≤1 cm) and 16 patients with large nodule (length-diameter of the largest thyroid nodule>1 cm).Compared with non-nodule group,the age of patients were older in nodule group (P<0.05).There was no significant difference in gender,weight,131I dose/g of thyroid tissue,the highest radioactive iodine uptake,texture,and incidence of exophthalmos,hyperthyroid heart disease,liver function impairment and leukopenia(P>0.05).51 of 75 patients were cured,the total curative rate was 68.00% and total effective rate was 97.33%,there was no significant difference in efficacy of 131I therapy between two groups.The curative rate of hyperthyroid patients with small nodule,large nodule and without nodule was 81.25%,43.75% and 72.09%,respectively.The curative rate of hyperthyroid patients with large nodule was lower than that of hyperthyroid patients without nodule (P=0.04) and hyperthyroid patients with small nodule(P=0.03),and there was no significant difference in efficacy of 131I therapy between hyperthyroid patients with small nodule and hyperthyroid patients without nodule found by using hierarchical analytical methods.Conclusions Compared with non-nodule patients with Graves' hyperthyroidism,the age is older in hyperthyroid patients with thyroid nodule.Efficacy of 131I therapy of the two groups are both favorable,while the efficacy of hyperthyroid patients with large thyroid nodule is less effective.关键词
甲状腺功能亢进症/甲状腺结节/碘放射性同位素/超声检查/治疗结果Key words
Hyperthyroidism/Thyroid nodule/Iodine radioisotopes/Ultrasonography/Treatment outcome分类
医药卫生引用本文复制引用
姚晓波,祝捷,程义壮,张然,金晓毛,夏俊勇,洪波,罗玲玲,张丹凤,章清荷,叶山东..超声检查甲状腺功能亢进症伴有甲状腺结节患者的临床特点和131碘治疗效果分析[J].中国临床保健杂志,2017,20(4):404-407,4.基金项目
安徽省卫生厅医学科研课题(13zc005) （13zc005）
