中国临床保健杂志2017，Vol.20Issue(4)：462-465,4.DOI:10.3969/J.issn.1672-6790.2017.04.040
微小核糖核酸在骨关节炎中的研究进展
Research progress of microRNAs in osteoarthritis
摘要
Abstract
Osteoarthritis (OA) is a chronic progressive osteoarthrosis characterized by articular cartilage degeneration and peri-articular bone hyperplasia,which is associated with an increase in age.Chondrocyte phenotype,cartilage changes in the steady state and subchondral bone metabolism are the inseparable part of the development of osteoarthritis.MicroRNA belongs to the endogenous non-coding protein of single-stranded small RNA,mainly through the regulation of gene transcription level,and then control tissue growth and steady state.Based on the miRNA gene regulation mechanism,this paper reviews the relationship between miRNA and articular cartilage,miRNA and pain,miRNA and inflammatory response,then provides a new strategy for clinical treatment.关键词
骨关节炎/微RNAs/基因表达调控Key words
Osteoarthritis/MicroRNAs/Gene expression regulation分类
医药卫生引用本文复制引用
周荣伟,赵丽珂,王钱,黄慈波..微小核糖核酸在骨关节炎中的研究进展[J].中国临床保健杂志,2017,20(4):462-465,4.基金项目
首都卫生发展科研专项(BJ-2014-092) （BJ-2014-092）
