南京医科大学学报（自然科学版）2017，Vol.37Issue(5)：615-619,5.DOI:10.7655/NYDXBNS20170520
嗜神经侵袭对早期子宫颈癌预后的临床意义
Clinical prognosis significance of perineural invasion in early-stage cervical cancer
摘要
Abstract
Objective:To evaluate the prognostic significance of perineural invasion (PNI) in patients with early cervical cancer.Methods:We reviewed clinical records and pathology slides of 306 patients with cervical cancer (FIGO IA2ⅡA2) after radical hysterectomy in Department of Gynecology,Jiangsu Provincial People's Hospital From January 2008 to December 2015.Results:①The incidence of PNI in patients with early cervical cancer was 10.5％(32/306).②The incidence of PNI was correlated with tumor diameter,depth of invasion,lymphovascular spare invasion (LVSI) and lymph node metastasis (P＜0.05).③The disease-free survival and overall survival of the PNI-positive group were significantly lower than those of the PNI-negative group.④Univariate analysis showed that tumor diameter,PNI and clinical stage were correlated with the overall survival time of cervical cancer(P＜0.05).The tumor diameter was correlated with disease-free survival time (P=0.002).⑤Multivariate analysis showed that PNI was not identified as an independent risk factor(P=0.154).Conclusion:The PNI is associated with tumor diameter,depth of invasion,LVSI and lymph node metastasis,and affect the prognostic of cervical cancer,but is not an independent risk factor.关键词
子宫颈癌/嗜神经侵袭/预后/危险因素Key words
cervical cancer/perineural invasion/prognosis/rick factors分类
医药卫生引用本文复制引用
顾嘉敏,袁琳,程文俊,韩素萍,尤志学,傅士龙..嗜神经侵袭对早期子宫颈癌预后的临床意义[J].南京医科大学学报（自然科学版）,2017,37(5):615-619,5.基金项目
江苏省妇幼健康科研项目(F201438) （F201438）
