日用化学工业2017，Vol.47Issue(5)：272-276,5.DOI:10.13218/j.cnki.csdc.2017.05.007
广藿香精油抗炎祛痘功效研究
Anti-acne efficacy of essential oil from Pogostemon cablin (Blanco)Benth
摘要
Abstract
Chemical composition of the essential oil from Pogostemon cablin (Blanco)Benth. (EOP)was quantitatively analyzed by gas chromatography-mass spectrometry (GC-MS). The safe mass concentration of the EOP to Human Acute Mononuclear Cells (THP -1 )was determined via cytotoxicity screening test. An inflammatory acne model was established by stimulating THP -1 with Propionibacterium acnes (P. acnes ). Subsequently,the effect of the EOP on the expression of proinflammatory cytokine IL-1β was assessed. The anti-acne mechanism of the EOP was examined by qRT -PCR. Results show that at maximum safe mass concentration of 12. 5 mg/L of the EOP,the influence on the activity of P. acnes is rather small and the secretion of IL-1β is significantly inhibited by a rate of 66. 54%. The EOP also significantly reduces the mRNA level of Toll-like receptor 2 (TLR2)by 73. 73%. Thereby,the EOP inhibits proinflammatory signal transduction and production of secondary inflammatory mediators.关键词
化妆品添加剂/广藿香精油/抗炎祛痘/痤疮丙酸杆菌Key words
cosmetic additive/essential oil from Pogostemon cablin/anti-acne/Propionibacterium acnes广藿香(Pogostemon cablin (Blanco)Benth. )为唇分类
化学工程引用本文复制引用
王癑,郭苗苗,施雁勤,潘仙华,卢艳花,曹平..广藿香精油抗炎祛痘功效研究[J].日用化学工业,2017,47(5):272-276,5.基金项目
教育和科研协同创新计划——上海市香料香精及化妆品协同创新中心资助项目(1021ZK162001) （1021ZK162001）
