四川中医2017，Vol.35Issue(4)：66-68,3.
大黄素对哮喘小鼠肺组织形态及BALF中炎性细胞因子分泌水平的影响
Effects of Emodin on the Pulmonary Histology and the Inflammatory Cytokine Levels of BALF in Asthma Mice
摘要
Abstract
Objective:To explore the effects of emodin on lung inflammation and inflammatory cytokine levels in BALF of mice with OVA-induced asthma.Methods:The method of OVA sensitization and challenge was used to establish bronchial asthma mice models.20 female C57BL/6 mice were randomly divided into normal group,model group,emodin group and positive controlled group.Each medication group was given relevant medicine for gavage.The overall situations as well as morphological changes from all groups were observed.The levels of cytokines in BALF of mice were detected.Results:Mice from the model group showed shortness of breath,wheezing,sneezing,scratching ear and nose,fecal incontinence etc.Compared with the controlled group,their pulmonary histological results showed a large number of inflammatory cells infiltrated around the bronchi and vessels,uncompletedalveolar structure associated with bronchial epithelial damage and even fibrosis change.What' s more,their levels of IL-4,IL-5,IL-17A in BALF significantly increased (P ＜ 0.01),compared with the controlled group.After treatment with emodin,the above symptoms,signs and pathologic changes from asthmatic mice were alleviated.Their inflammatory levels were also reduced.Conclusion:Emodin might alleviate pulmonary inflammation of bronchial asthma mice modelprobably through inhibiting the levels of IL-4,IL-5,IL-17A.关键词
大黄素/支气管哮喘/白介素-4/白介素-5/白介素-17AKey words
Emodin/Bronchial asthma/Interleukin-4/Interleukin-5/Interleukin-17 A分类
医药卫生引用本文复制引用
吴佳佳,钟大玲,刘茈蕊,葛东宇,李根茂,吴珺,彭桂英..大黄素对哮喘小鼠肺组织形态及BALF中炎性细胞因子分泌水平的影响[J].四川中医,2017,35(4):66-68,3.基金项目
国家自然科学基金面上项目(编号:81473656) （编号:81473656）
北京中医药大学创新团队(编号:2011-CXTD-04) （编号:2011-CXTD-04）
