四川中医2017，Vol.35Issue(4)：72-75,4.
活血利湿方对非酒精性脂肪肝大鼠肝功及肝脏病理的影响
Effect of Promote-blood-circulation and Remove-dampness Decoction on Liver Function and Liver Pathology for Non-Alcoholic Fatty Liver Rats
摘要
Abstract
Objective:To study the effect of Promote-blood-circulation and Remove-dampness Decoction (PARD) on liver function and pathological changes in SD rats with non-alcoholic fatty liver disease (NAFLD).Methods:8 rats fed with general diet were taken as blank controlled group.To induce NAFLD,a high-fat diet was given to SD rats of prevention group (n =8) and model group (n =27).During this period,the rats in prevention group were fed PARD by gastric perfusion.After 8 weeks,2 rats were selected from model group randomly and were killed to decide the animal model was successful by observing pathological changes in the liver.Rats in the blank controlled group,the prevention group and the model group (7 of them) were executed to obtain the plasma and liver tissues.All the liver tissues were stained with Hematoxylin-Eosin (HE),the tissue of rats in the model group were histologically analyzed and the animal model was successful.The effect of PARD on serum levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),lactate dehydrogenase (LDH) were detected during the period of model building.Meanwhile,all the liver tissues were observed to learn pathological changes.Results:The levels of ALT had no difference between the blank controlled group and the model group (P ＞ 0.05).Compared with the blank controlled group,the levels of AST,LDH in the model group were rise (P ＜ 0.05).The prevention group had lower (P ＜ 0.05) levels of AST,LDH compared with the model group.NAS score and inflammatory status were all reduced in the PARD group (P ＜ 0.05),compared with the model group.Conclusion:PARD can improve liver function,liver pathological morphology and reduce the degree of hepatic inflammation of rats with NAFLD.关键词
非酒精性脂肪肝/中药防治/活血利湿方Key words
Non-alcoholic fatty liver disease/Prevention and treatment by Chinese herbs/Promote-blood-circulation and Remove-dampness Decoction分类
医药卫生引用本文复制引用
徐春霞,刘智群,缪伟峰,杨勤..活血利湿方对非酒精性脂肪肝大鼠肝功及肝脏病理的影响[J].四川中医,2017,35(4):72-75,4.基金项目
南京市中医院院级课题—活血利湿方对非酒精性脂肪肝大鼠防治作用及其机制研究(编号:YJ201406) （编号:YJ201406）
