摘要
Abstract
Objective:To investigate the effects of Modified Liuwei Dihuang Pills facilitating Metformin on inflammatory factor and blood glucose indicator of patients with type 2 diabetes mellitus (T2DM).Methods:146 cases of T2DM patients with syndrome of endogenous heat due to Yin deficiency who accepted treatment from February 2013 to February 2015 were selected as the objects of study.According to the admission time,the patients were divided into controlled group and observation group,with 73 cases in each group.The controlled group was treated by oral administration of Metformin Hydrochloride Tablets,and the observation group treated by Modified Liuwei Dihuang Pills facilitating Metformin.The course of treatment of the two groups was 3 months.The serum inflammatory factors,blood glucose indicator,clinical efficacy and adverse drug reaction of the two groups were compared.Results:The total effective rate of the observation group was 93.15％,which was significantly higher than that of the controlled group (75.34％) (x2 =8.722,P ＜ 0.05);the levels of inflammatory factors tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6)and interleukin-8 (IL-8)were respectively (1.29±0.20) ng/L,(55.63±10.49) ng/L and (5.17±0.59) ng/L,all of which were significantly lower than those of the controlled group (t=4.831,3.836,6.108,P ＜ 0.05);the blood glucose levels of fasting blood glucose (FBG),postprandial 2 hour peripheral blood glucose (2hPG) and glycosylated hemoglobin Alc (HbAlc)were respectively (6.31±0.85)mmol/L,(6.60±0.83)mmol/L and (6.24±0.97) ％,all of which were significantly lower than those of the controlled group (t=6.454,10.174,6.220,P ＜ 0.05).There were no serious adverse drug reactions in the two groups.The incidence rates of mild gastrointestinal reactions of the observation group and the controlled group were 12.33％ and 9.59％,respectively,and the difference was not statistically significant (x2 =0.280,P ＜ 0.05).Conclusions:Modified Liuwei Dihuang Pills facilitating Metformin can effectively reduce the inflammatory reactions of type 2 diabetic patients with syndrome of endogenous heat due to Yin deficiency,control the blood glucose level,improve the therapeutic effect and has good security.关键词
2型糖尿病/六味地黄丸/二甲双胍/炎性因子/血糖指标Key words
Type 2 diabetes mellitus/Liuwei Dihuang Pills/Metformin/Inflammatory factor/Blood glucose indicator分类
医药卫生
