四川中医2017，Vol.35Issue(6)：155-157,3.
痛泻要方加味治疗肝郁脾虚腹泻型肠易激综合征临床观察
Clinical Observation of Modified Tongxieyao Formula for Liver Depression and Spleen Deficiency Type Diarrhea Predominant Irritable Bowel Syndrome
摘要
Abstract
Objective:To observe the clinical efficacy and adverse effect of Modified Tongxieyao Formula for diarrhea predominant irritable bowel syndrome (IBS-D) of liver depression and spleen deficiency pattern,and comparing the effect of combining Pinaverium Bromide and Montmorillonite Powder.Methods:74 patients diagnosed with IBS-D of liver depression and spleen deficiency pattern were randomly divided into two groups,36 in treatment group and 38 in controlled group.Patients in the treatment group were treated by Modified Tongxieyao Recipe while those in the controlled group were given combination of Pinaverium Bromide and Montmorillonite Powder.Treatment in both groups lasted for 4 weeks,and the clinical efficacy and the recurrence rate were evaluated afterwards.Results:After treatment,the comprehensive effect,including alleviation of symptoms like diarrhea,abdominal pain,irritability,poor appetite and so on,was superior to that of the controlled group,with statistical significance (P ＜ 0.05).There was no statistical significance between the treatment group (44.44％) and the controlled group (61.90％) regarding to recurrence rate within 3 months.Conclusion:Modified Tongxieyao Formula is indeed effective for treatment of diarrhea predominant irritable bowel syndrome (IBS-D) of liver depression and spleen deficiency pattern,and superior to therapeutic effect of combination of Pinaverium Bromide and Montmorillonite Powder regarding to symptoms alleviation like diarrhea,abdominal pain,irritability,poor appetite and so on.Yet there is no significant difference in recurrence prevention between the 2 groups.关键词
腹泻型肠易激综合征/肝郁脾虚证/痛泻要方/疗效观察Key words
Diarrhea predominant irritable bowel syndrome (IBS-D)/Liver depression and spleen deficiency pattern/Tongxieyao Formula/Curattive observation分类
医药卫生引用本文复制引用
王建国,杜勇军,黄粲宸,周策,袁可,余乐来,陈敏,黄德铨..痛泻要方加味治疗肝郁脾虚腹泻型肠易激综合征临床观察[J].四川中医,2017,35(6):155-157,3.基金项目
国家自然科学基金面上项目(No.81373644):基于脑肠轴双向调节假说研究痛泻要方抑木组分白芍防风缓解IBS-D内脏高敏的机制 （No.81373644）
四川省中医药管理局项目(NO.2016C075):等离子体手术系统结合中药熏洗治疗高位单纯性肛瘘的多中心临床随机对照研究. （NO.2016C075）
