生物医学工程研究2017，Vol.36Issue(2)：164-167,4.DOI:10.19529/j.cnki.1672-6278.2017.02.14
温敏型阴道酸缓冲原位凝胶的制备与质量评价
Preparation and Quality Evaluation of Thermosensitive Vaginal Acid Buffer in-situ Gel
摘要
Abstract
To prepare a thermosensitive gel,which is liquid in room temperature and undergoes a phase transition to bioadhesive gel at body temperature.The transition is rapid that make it is easy to spread out and attatch to vaginal wall and cervix uterus,and help the vaginal wall and cervix uterus make contact with the gel.The existence of acid buffer system can maintain pH between 3.5 to 4.5 in vaginal wall,thus acid ambient can be recoverd.The in-situ vaginal gels administered intravaginally had no significant systemic and local toxicity.And it is not irritative to vaginal in rabit.This product has no sensitization to skin.The gel has bacteriostasis and spermatocidal effects.关键词
原位凝胶/酸缓冲体系/阴道滞留/阴道刺激性/抑菌Key words
in-situ gels/acid buffer system/vaginal retention/vaginal irritation/bacteriostasis分类
医药卫生引用本文复制引用
徐伟娜,杨清华,王勤,王传栋,刘林,颜红..温敏型阴道酸缓冲原位凝胶的制备与质量评价[J].生物医学工程研究,2017,36(2):164-167,4.基金项目
山东省科技计划项目(2007GG20002013). （2007GG20002013）
