山东医药2017，Vol.57Issue(24)：20-23,4.DOI:10.3969/j.issn.1002-266X.2017.24.006
妊娠糖尿病患者孕中晚期血清GLP-1水平变化及临床意义
Changes and clinical significance of serum glucagon like peptide-1 during 24 to 28 gestational weeks in patients with gestational diabetes
摘要
Abstract
Objective To investigate the changes in levels of serum glucagon-like peptide 1 (GLP-1) in the second and third trimesters of pregnant women with gestational diabetes mellitus (GDM) and its clinical significance.Methods A total of 82 pregnant women receiving antenatal care regularly were enrolled, including 40 cases of GDM patients (GDM group) and 42 cases of normal glucose tolerance subjects (control group).The pregnant women in both groups received oral glucose tolerance test (OGTT) after taking 75 g glucose during the 24-28 weeks of gestation.The serum GLP-1 and area under the GLP-1 curve (AUCGLP-1), the serum insulin (INS)/GLP-1 and area under the insulin curve (AUCINS)/area under the blood glucose curve (AUCGL)-1 were measured at 0, 30, 60, and 120 min after glucose administration.We analyzed the correlations between serum GLP-1, AUCGLP-1, blood glucose, AUCGLU, INS, and AUCINS in GDM patients.Results The level of INS/GLP-1 in the GDM group at 30 min was lower than that of the control group (P<0.05).However, there were no statistically significant differences in the levels of serum GLP-1, AUCGLP-1, and AUCINS/AUCGLP-1 between these two groups (all P>0.05).For GDM patients, the level of serum GLP-1 was not correlated with GLU, INS, and AUCGLU at 0, 30, 60, and 120 min after glucose administration (all P>0.05), but GLP-1 was positively correlated with AUCGLP-1 (r=0.243, P<0.05) and AUCINS (r=0.270, P<0.05).There was a positive correlation between AUCGLP-1 and INS at 60 min (r=0.013, P<0.05) and 120 min (r=0.041, P<0.05).Conclusion Compared with normal glucose tolerance subjects, the level of serum GLP-1 in GDM patients does not change significantly, but exists the tendency of peak delay.There may be a relative deficiency of GLP-1 secretion at 30 min after 75 g OGTT, which indicates that GDM patients may have GLP-1 resistance.关键词
妊娠糖尿病/胰高血糖素样肽1/葡萄糖耐量试验/血糖/胰岛素Key words
gestational diabetes mellitus/glucagon like peptide-1/oral glucose tolerance test/glucose/insulin分类
医药卫生引用本文复制引用
冯莉,滕佳丽,李晓瑾,周玲,刘彦君..妊娠糖尿病患者孕中晚期血清GLP-1水平变化及临床意义[J].山东医药,2017,57(24):20-23,4.基金项目
国家自然科学基金资助项目(21331001) （21331001）
国家科技重大专项子课题(2011ZX09307-001-08) （2011ZX09307-001-08）
北京市科技计划(Z161100000516010) （Z161100000516010）
北京市自然科学基金资助项目(7122109). （7122109）
