实用肝脏病杂志2017，Vol.20Issue(4)：455-459,5.DOI:10.3969/j.issn.1672-5069.2017.04.019
经琢-干扰素和核苷(酸)类似物治疗的慢性乙型肝炎患者原发性肝癌发生率比较研究
A comparative study of impact of interferon alpha and nucleos(t)ide analogues in treating patients with chronic hepatitis B on incidence of hepatocellular carcinoma
汪顺才 1王兵 2马洁 3马久明 1周华 1虞腊青 1经继生1
作者信息
- 1. 212400 江苏省句容市 江苏大学附属句容人民医院
- 2. 安徽省生物研究所
- 3. 江苏大学医学院
- 折叠
摘要
Abstract
Objective The aim of this study is to compare the impact of interferon alpha and nucleos(t)ide analogues in treating patients with chronic hepatitis B on incidence of hepatocellular carcinoma. Methods A series of patients with chronic hepatitis B (CHB) aged 30 to 60 years old were enrolled between January 2007 and December 2010 in our hospital. 210 patients with CHB were treated with interferon alpha 2b (IFN-α2b) for 72 weeks, 222 with nucleos (t)ide analogues (NAs) as a long-term treatment and 136 cases didn't received antiviral therapy. All the patients were followed-up for six years. All data were analyzed by SPSS 19.0 statistics software. Results At the end of 72 week treatment,serum HBeAg positivity rate in IFN-α2b-treated group was much lower than in NAs-treated or in non-antiviral group (P<0.05),while serum HBV DNA and alanine aminotransferase levels in NAs-treated group were much lower than in IFN-α2b-treated group or in non-antiviral group (P<0.05);serum chileglycine,collagen peptide Ⅲ,Ⅳ collagen,hyaluronic acid and laminin levels in IFN-α2b-or NAs-treated group were not significantly different (P>0.05),while all were much lower than in non-antiviral group (P<0.05);At the discontinuation of six year follow-up,the incidence of HCC in non-antiviral group was 16.91%(23/136),much higher than 9.46%(21/222,x2=4.345,P=0.037) in NAs-treated or 0.0% (0/210,x2=38.044,P=0.000) in IFN-α2b-treated group,and the incidence of HCC in NAs-treated group was much higher than in IFN-α2b-treated group (x2=20.880,P=0.000). Conclusions The efficacy of IFN-α2b therapy on HCC occurrence in patients with CHB is much stronger than NAs treatment.关键词
肝细胞癌/慢性乙型肝炎/干扰素α/核苷(酸)类似物/治疗Key words
Hepatocellular carcinoma/Hepatitis B/Interferon α/Nucleos(t)ide analogues/Therapy引用本文复制引用
汪顺才,王兵,马洁,马久明,周华,虞腊青,经继生..经琢-干扰素和核苷(酸)类似物治疗的慢性乙型肝炎患者原发性肝癌发生率比较研究[J].实用肝脏病杂志,2017,20(4):455-459,5.
