实用肝脏病杂志2017，Vol.20Issue(4)：472-476,5.DOI:10.3969/j.issn.1672-5069.2017.04.023
经导管肝动脉化疗栓塞联合射频消融治疗原发性肝癌患者临床疗效评价
Clinical efficacy of TACE and radiofrequency ablation in treatment of patients with primary liver cancer
摘要
Abstract
Objective To evaluate the clinical efficacy of TACE and radiofrequency ablation (RFA) in treatment of patients with primary liver cancer (PLC). Methods Sixty patients with PLC in the center of liver diseases in our hospital between April 2012 and March 2013 were randomly divided into two groups,with 30 cases in each group,and the patients were given RFA after TACE or TACE alone therapy. The short-and long-term clinical response were compared. Results There was no significant difference at baseline between the two groups as respect to gender,age,hepatitis B surface antigen positive,liver function index,α-fetoprotein (AFP), tumor numbers and tumor diameters (P>0.05);the complete and partial remission rates in the combination group (26.7% and 50.0%,respectively)were much higher than those (6.7% and 23.3%,respectively)in the TACE group (P<0.05);the survival periods in the combination group (2.86±0.48 years)was much longer than that (0.93±0.27 years)in the TACE group (P<0.05);serum AFP level at the end of first,second and third year after treatment in the combination group[(475.4±200.7)μg/L,(416.4±229.0)μg/L and (320.4±243.5)μg/L] were lower than those [(639.1±190.9)μg/L,(623.4±234.6)μg/L and(674.4±300.2 )μg/L] in TACE group (P<0.05);the 1 a,2 a and 3 a survival rates after treatment in the combination group (86.7%,66.7% and 56.7%) were significantly higher than those(46.7%,26.7% and 10.0%)in the TACE group(P<0.05). Conclusion Combination of TACE and RFA has a remarkable clinical efficacy for patients with PLC,which is worthy of further investigation.关键词
原发性肝癌/经导管肝动脉化疗栓塞/射频消融/治疗Key words
Hepatoma/Transcatheter arterial chemoembolization/Radiofrequency ablation/Therapy引用本文复制引用
张伟,陈刚,孙密密,安永,王永清,商庆华..经导管肝动脉化疗栓塞联合射频消融治疗原发性肝癌患者临床疗效评价[J].实用肝脏病杂志,2017,20(4):472-476,5.基金项目
原济南军区"十一五"科研计划课题(编号:J115N009) （编号:J115N009）
泰安市科技发展计划课题(编号:2015NS1132) （编号:2015NS1132）
