实用医学杂志2017，Vol.33Issue(9)：1449-1452,4.DOI:10.3969/j.issn.1006-5725.2017.09.022
肌钙蛋白I在脓毒性休克致左心室舒张功能障碍患者中的变化和意义
Significance of Troponin-I in patients with septic shock and left ventricular diastolic dysfunction
摘要
Abstract
Objective To investigatethe clinical value of troponin-I(cTnI)in patientswith septic shocka-nd left ventricular diastolic dysfunction. Methods As a retrospective analysis ,38 patients with left ventricular di-astolic dysfunction and septic shock(Sa group),as well as 20 patients with normal cardiac function(Sn group) were enrolled in this study. Moreover ,20 patients with left ventricular diastolic dysfunction and without septic shock were used as control group(Ca group). The ratio of early diastolic mitral inflow velocity to early diastolic mi-tral annulus velocity(E/e′)was measured as the evaluation index of left ventricular diastolicfunction by echocar-diography within 72 hours after admission to ICU. Level of cTnI was detected in all cases and the relationship was evaluated by E/e′. Receiver operating characteristic curve(ROC)was constructed to indicate the predictable value of left ventricular diastolic dysfunction in patients with septic shock. Results The level of cTnI was significantly elevated in both Sa group and Sn group(P<0.05),while the level of cTnI and E/e′in Sa group were significantly higher than those in Sn group(P < 0.05). cTnI was positively correlated with E/e′(r = 0.367 ,P = 0.004). The area under the curve(AUC)of cTnI was 0.834,with the cut-off value of 0.49 ng/mL(sensibility=77.6,specificity=80.7). Conclusion The level of cTnI was significantly higher in patients with septic shock. cTnI was significantly correlated to left ventricular diastolic dysfunction in patients with septic shock. cTnI ≥ 0.49 ng/mL could be an available predictor for left ventricular diastolic dysfunction in patients with septic shock.关键词
脓毒性休克/左心室舒张功能/肌钙蛋白IKey words
Septic shock/Left ventricular diastolic function/Troponin-I引用本文复制引用
夏嘉鼎,苏震,王娜,秦诗阳,赵凯峰..肌钙蛋白I在脓毒性休克致左心室舒张功能障碍患者中的变化和意义[J].实用医学杂志,2017,33(9):1449-1452,4.基金项目
河北省科技支撑计划项目(编号:152777205) （编号:152777205）
