摘要
Abstract
Objective:To study the relationship between AMH levels and ovarian reserve & reactivity,and explore the modified CONSORT formula for individualized dosing of FSH.Methods:The data of 130 infertile patients aged 23 to 40 who were treated with GnRH agonist long protocol in our reproductive center from Oct.2015 to Apr.2016 were retrospectively analyzed.Based on the CONSORT formula proposed by Howles,firstly,the new variable AMH was introduced into the formula (modified CONSORT formula);Secondly the initial FSH dose was replaced by average FSH dose in the formula (corrected CONSRT formula);Finally,the initial FSH dose was replaced by average FSH dose while the AMH variable was introduced into the formula (corrected & modified CONSRT formula).The classical CONSORT formula,modified CONSORT formula,corrected CONSORT formula and corrected & modified CONSORT formula were obtained by multiple linear regression analysis.After the formulas are obtained,the number of theoretical oocytes retrieved was obtained by substituting the variables,and then the relationship between theoretical oocytes retrieved and the actual number of oocytes retrieved was analyzed.The merits and weakness of each formula was analyzed and verified.Results:(1) AMH level was negatively correlated with age,FSH level,FSH initial dose or FSH average dose,and positively correlated with the number of oocytes retrieved.(2) The number of oocytes retrieved was positively correlated with the FSH average dose,but the initial FSH dose was not significantly correlated with the number of retrieved oocytes.The statistical results show that the modified CONSORT formula(R 2=0.694,P<0.0001,Σ(S-Y) 2=15.42)is better than the classical CONSORT formulas(R 2=0.693,P<0.0001,Σ(S-Y) 2=17.05).The corrected CONSORT formula(R 2=0.696, P<0.000 1,Σ(S-Y) 2=13.91)was better than the classical CONSORT formulas;and the corrected & modified CONSORT formula(R 2=0.698,P~0,Σ(S-Y) 2=10.87)was better than the other three formulas.Conclusions:AMH level can predict the ovarian reserve and response.Corrected & modified CONSORT algorithm can predict ovarian response and the patient's treatment outcome more accurately.It is helpful to accurately guide the FSH initial dose.关键词
抗苗勒管激素/控制性促排卵/体外受精-胚胎移植/长方案/CONSORT公式Key words
Anti-Mullerian Hormone/Controlled ovarian hyperstimulation/IVF-ET/GnRH agonist long-protocol/CONSORT algorithm
