生殖医学杂志2017，Vol.26Issue(7)：670-674,5.DOI:10.3969/j.issn.1004-3845.2017.07.010
PCOS高雄激素血症患者降调节后行冻融胚胎移植的临床结局观察
Clinical outcomes of frozen-thawed embryo transfer cycles after pituitary down-regulation in patients with polycystic ovary syndrome and hyperandrogenism
摘要
Abstract
Objective:To explore the influence of pituitary down-regulation on clinical outcomes of frozen-thawed embryo transfer cycles in patients with polycystic ovary syndrome (PCOS) and hyperandrogenism.Methods:A retrospective analysis was performed in 139 patients with PCOS and hyperandrogenism undergone frozen embryo transfer (FET) in the reproductive medicine center of Jiangsu Huai'an Maternity and Children Hospital from January 2012 to April 2016.The patients were divided to two groups according to the different endometrial preparation scheme:hormone replacement group (group A,n=76) and hormone replacement combined with pituitary down-regulation group (group B,n=63).The time and dose of estrogen use,endometrial thickness and type,serum hormone levels and clinical outcomes were compared between the two groups.Results:No significant differences were found in endometrial thickness on embryo transfer day,number of transferred embryos,quality embryo rate,early miscarriage rate and ectopic pregnancy rate between the two groups (P>0.05).The duration [(13.67±1.91) vs.(15.28±2.47) days] and dosage [(81.55±10.80) vs.(94.25±14.17) mg] of progynova used in group B was significantly less than group A (P<0.01).The type A endometrium on embryo transfer day (77.78% vs.57.89%),the clinical pregnancy rate (69.84% vs.51.31%)and implantation rate (47.29% vs.32.47%) in group B were significantly higher than group A (all P<0.05).Conclusions:Hormone replacement combined with pituitary down-regulation is an effective and convenient method for frozen-thawed embryo transfer cycles in patients with polycystic ovary syndrome and hyperandrogenism with less usage of estrogen,better classification of endometrium,higher pregnancy rate and embryo implantation rate.关键词
降调节/多囊卵巢综合征/高雄激素血症/冻融胚胎移植Key words
Down-regulation/Polycystic ovary syndrome (PCOS)/Hyperandrogenism/Frozen-thawed embryo transfer引用本文复制引用
魏勉,邱峰龙,薛惠英..PCOS高雄激素血症患者降调节后行冻融胚胎移植的临床结局观察[J].生殖医学杂志,2017,26(7):670-674,5.基金项目
江苏省中医药科技项目(YB2015128) （YB2015128）
