生殖医学杂志2017，Vol.26Issue(7)：675-678,4.DOI:10.3969/j.issn.1004-3845.2017.07.011
脱氢表雄酮对卵巢储备功能下降患者卵巢反应性和IVF-ET结局的影响
Efficacy of dehydroepiandrosterone to improve ovarian response and the outcome of IVF-ET in women with diminished ovarian reserve
摘要
Abstract
Objective:To investigate the efficacy of dehydroepiandrosterone (DHEA) to improve ovarian response and the outcome of IVF-ET in women with diminished ovarian reserve (DOR).Methods:The data were obtained from 58 DOR patients with 29 to 41 years old.The patients were and received GnRH-antagonist (GnRH-ant) protocol in the first cycle without DHEA treatment (control cycle);and the patients was given dehydroepiandrosterone at least for 2 months,and then received GnRH-antagonist (GnRH-ant) protocol in the second cycle (treatment cycle).The interval of two cycles was no more than one year.The dose and duration of gonadotropin (Gn) used,cycle cancellation rate,FSH levels,number of AFC and oocyte retrieved,oocyte retrieval rate,number of MII oocytes,normal fertilization rate,number of good embryos,good embryo rate and pregnant rate were compared between the two cycles by paired-samples t-test and Chi-square.Results:Gn dosage used was significantly lower in treatment cycles than that in the control cycles(31.4±1.4 vs.36.6±1.9 ampoules)(P<0.05).The oocyte retrieval rate (83.7% vs.74.1%)and pregnancy rate (37.7% vs.5.7%)in the treatment cycles were significantly higher than those in the control cycles(P<0.01).Conclusions:Dehydroepiandrosterone can improve ovarian function in DOR patients and increase oocyte retrieval rate and good-quality embryo rate,as well as IVF pregnancy rate.In addition,DHEA can decrease the Gn dosage used,therefore reduce the cost for patients.关键词
DHEA/卵巢储备功能下降/拮抗剂/体外受精-胚胎移植Key words
DHEA/Diminished ovarian reserve (DOR)/GnRH-antagonist/IVF-ET引用本文复制引用
龚瑜,周黎明,蔡婕,孙亦婷,赵雅云,夏爱丽..脱氢表雄酮对卵巢储备功能下降患者卵巢反应性和IVF-ET结局的影响[J].生殖医学杂志,2017,26(7):675-678,4.基金项目
宁波市自然基金项目(2015A610199) （2015A610199）
