生殖医学杂志2017，Vol.26Issue(7)：699-704,6.DOI:10.3969/j.issn.1004-3845.2017.07.016
芬吗通联合用药改善多囊卵巢综合征患者冻融胚胎移植周期子宫内膜血流及妊娠结局的研究
Femoston improves endometrial blood flow and pregnancy outcome in frozen-thawed embryo transfer cycle in patients with polycystic ovary syndrome
摘要
Abstract
Objective:To study the effect of different schedule of Femoston in endometrial blood flow and pregnancy rate in frozen-thawed embryo transfer (FET) cycle in patients with polycystic ovary syndrome (PCOS).Methods:The 245 FET cycles of patients with PCOS in the center of affiliated hospital of Shandong university of TCM reproduction and genetic from June 2015 to June 2016 were collected.The patients were randomly divided into progynova group (group A,81 cycles) and Femoston oral group (group B,78 cycles) and Femonston oral combined vaginal group (group C,86 cycles).The endometrial thickness and volume,vascularization index (VI),flow index (FI),and vascularization flow index (VFI) were measured and serum E 2 levels were detected on the progesterone transformation day.Results:The endometrial thickness and volume on progesterone transformation day were not significantly different among the three groups (P>0.05).The VI,FI and VFI in group C were significantly higher than those in group A or group B (P<0.05),but there were not significantly different between group A and group B (P>0.05).There were 79 transplant cycles in 81 FET cycles in group A,77 transplant cycles in 78 FET cycles in group B,and 85 transplant cycles in 86 FET cycles in group C.The cycle cancellation rate,duration of estrogen used,the levels of progesterone and LH on the progesterone transformation day,and miscarriage rate were not significantly different among the three groups (P>0.05).The serum E 2 levels on the progesterone transformation day,the implantation rate,the clinical pregnancy rate in group C were significantly higher than those in group A and group B (P<0.05),but there were not significantly difference between group A and group B (P>0.05).Conclusions:Oral administration combined with vaginal administration of Femonston is an ideal endometrial preparation,because it can significantly increase the serum E 2 levels and bioavailability,and promote the endometrial spiral arteries hyperplasia & the endometrial blood flow,and improve the implantation rate and clinical pregnancy rate in FET cycle on patients with PCOS.关键词
多囊卵巢综合征/冻融胚胎移植/内膜准备/芬吗通Key words
Polycystic ovary syndrome/Frozen-thawed embryo transfer/Endometrial preparation/Femoston引用本文复制引用
张宁,陈姗姗,杨文秀..芬吗通联合用药改善多囊卵巢综合征患者冻融胚胎移植周期子宫内膜血流及妊娠结局的研究[J].生殖医学杂志,2017,26(7):699-704,6.基金项目
国家自然科学基金资助项目(81273667) （81273667）
