天津工业大学学报2017，Vol.36Issue(3)：1-5,5.DOI:10.3969/j.issn.1671-024x.2017.03.001
PACMO-b-PDPA两亲性嵌段聚合物的合成及其纳米自组装
Synthesis of amphiphilic block copolymer PACMO-b-PDPA and its self-assembly
摘要
Abstract
For the preparation of pH-responsive Poly (N-acryloylmorpholine) based nano-drug carriers, a series of am-phiphilic block copolymer poly(acryloyl morpholine)-b-poly(2-(diisopropylamino)ethyl methacrylate) (termed as PACMO-CTA and PACMO-b-PDPA) with different PDPA chain length were synthesized via two-step re-versible addition fragmentation chain transfer (RAFT) polymerization. The structure of the products were char-acterized by Fourier transform infrared spectrum(FT-IR), proton nuclear magnetic resonance (1H-NMR)spec-trometry , gel permeation chromatography(GPC). The results showed that the molecular weight of the polymers were controlled and the molecular weight distribution was narrow (Mw/Mn<1.2) in accordance with the funda-mental characteristics of RAFT active polymerization. Moreover, the nanoparticles formed by self-assembly were spherical and the average particle size were less than 200 nm, which meet the requirement of nano-drug carriers.关键词
聚丙烯酰吗啉/聚2-(二异丙基氨基)乙基甲基丙烯酸酯/自组装/纳米粒Key words
poly acryloyl morpholine(PACMO)/poly 2-(diisopropyl amino)ethyl methacrylate(PDPA)/self-assembly/nanoparticles分类
化学化工引用本文复制引用
陈莉,杨雪,赵军强,赵义平..PACMO-b-PDPA两亲性嵌段聚合物的合成及其纳米自组装[J].天津工业大学学报,2017,36(3):1-5,5.基金项目
国家自然科学基金资助项目(81502624) （81502624）
