现代妇产科进展2017，Vol.26Issue(6)：405-408,4.DOI:10.13283/j.cnki.xdfckjz.2017.06.001
高脂饮食诱导胰岛素抵抗对于大鼠子宫内膜的影响
The effect of insulin resistance on endometrium of Sprague Dawley rats
摘要
Abstract
Objective:To compare the effect of insulin resistance and high level of estrogen on endometrium in insulin resistance rat model.Methods:Female Sprague-Dawley rats were given high fat diet to induce insulin resistance for 40 weeks.Rats were then ovariectomized and administered with 17-β estradiol.Rats under sham operation were used as control group.Insulin resistance was confirmed by glucose tolerance test,insulin tolerance and homeostasis model assessment of insulin resistance index and blood lipid profile.The effect of estrogen was confirmed by Papanicolaou staining.Endometrial hyperplasia was detected by histopathology.Results:The area under curve of glucose tolerance and insulin tolerance and HOMA-IR was higher in rats with high fat diet.After administrated with estradiol,mature vaginal epithelial cell and endometrial hyperplasia were observed.Compared with rats with normal glucose metabolism,the percentage of squamous epithelial metaplasia was increased in rats with insulin resistance.Hypereosinophilia was observed endometrial stroma.Conclusion:Hyperinsulinemia might be related to endometrial hyperplasia and squamous epithelial metaplasia.关键词
胰岛素抵抗/子宫内膜增殖/动物模型Key words
Insulin resistance/Endometrial hyperplasia/Rat model分类
医药卫生引用本文复制引用
尚晨光,张岩,王小慧,冯宗昊,刘林枝..高脂饮食诱导胰岛素抵抗对于大鼠子宫内膜的影响[J].现代妇产科进展,2017,26(6):405-408,4.基金项目
国家自然科学基金资助项目(No:81272870) （No:81272870）
