中国组织工程研究2017，Vol.21Issue(16)：2461-2466,6.DOI:10.3969/j.issn.2095-4344.2017.16.001
膝骨关节炎严重程度与抵抗素水平的相关性
Correlation between resistin level and severity of knee osteoarthritis
摘要
Abstract
BACKGROUND: Resistin has been shown to play an important role in the pathogenesis and progression of osteoarthritis. OBJECTIVE: To investigate the correlation between resistin level in serum and synovial fluid and the severity of knee osteoarthritis. METHODS: Seventy-four patients with knee osteoarthritis and 79 healthy individuals were recruited. The Noyes score method was used to assess articular cartilage damage arthroscopically. The severity of knee osteoarthritis was evaluated according to the Western Ontario McMaster University Osteoarthritis (WOMAC) score. The radiographic severity of knee osteoarthritis was assessed by the Kellgren-Lawrence (K-L) grading system. The levels of resistin and cross linked C-telopeptide of type Ⅱ collagen (CTX-Ⅱ) in serum and synovial fluid were determined by ELISA. RESULTS AND CONCLUSION: The resistin level in the synovial fluid was positively correlated with the radiographic severity of knee osteoarthritis, WOMAC pain, WOMAC function, and WOMAC total scores, but showed no correlation with the WOMAC stiffness score. There were no significant correlations between the serum level of resistin and WOMAC total scores, subscale or K-L Grading system in the the osteoarthritis patients. Multiple regression analysis showed that the correlation between the synovial fluid level of resistin and WOMAC scores was of significance after removal of other confounding factors, and the resistin level in the synovial fluid was positively correlated with Noyes scores and CTX-Ⅱ level. These results suggest that the resistin level in the synovial fluid can serve as a potential biomarker reflecting the severity of knee osteoarthritis and cartilage degenerative degree in patients with osteoarthritis.关键词
组织构建/骨组织工程/骨关节炎/抵抗素/关节滑液/生物标记物分类
医药卫生引用本文复制引用
宋永周,关健,李明,马维,童九辉,苏瑞红..膝骨关节炎严重程度与抵抗素水平的相关性[J].中国组织工程研究,2017,21(16):2461-2466,6.基金项目
河北省医学科学研究重点课题(20150666)Funding: the Key Subject of Medical Research of Hebei Province, No. 20150666 （20150666）
