中国组织工程研究2017，Vol.21Issue(16)：2478-2483,6.DOI:10.3969/j.issn.2095-4344.2017.16.004
跑台运动干预膝关节软骨全层缺损修复
Effect of treadmill exercise on the repair of full-thickness knee cartilage defects
摘要
Abstract
BACKGROUND: As the articular cartilage has a special anatomical position, its function is often affected by movement. Whether exercise training can promote the cartilage repair still needs to be confirmed. OBJECTIVE: To investigate the effects of different intensities of treadmill exercises on the repair of full-thickness articular cartilage defects in rats. METHODS: Forty rats were selected, and the models of full-thickness articular cartilage defects (3.2 mm in diameter) on the femoral surface were made with a orthopedic drill, followed by randomized into model, low-, moderate- and high-intensity exercise groups (n=10 per group). The rats in the model group were allowed free cage activity. The rats in the low-intensity exercise group exercised on the platform, and the platform speed was 8.2 m/min; rats in the middle-intensity exercise group exercised on the 5° treadmill, and the speed was controlled at 15.5 m/min; rats in the high-intensity exercise group exercised on the 10° treadmill, and the speed was controlled at 26.7 m/min. RESULTS AND CONCLUSION: The levels of serum matrix metalloproteinase-3 and inhibitor of matrix metalloproteinase in the latter three groups were significantly lower than those in the model group at 8 weeks after exercise (P < 0.05), and the level was the lowest in the moderate-intensity exercise group (P < 0.05). In the moderate-intensity exercise group, there were fibrous tissues in the defect area, which were connected with the adjacent cartilage, and the repair effect was superior to that in the other three groups. To conclude, moderate-intensity treadmill exercise can promote the repair of full-thickness knee cartilage defects in rats, thereby improving functional recovery of the rat knee joint.关键词
组织构建/软骨组织工程/软骨缺损/跑台运动/膝关节软骨/基质金属蛋白酶3/关节功能/全层软骨缺损模型/纤维细胞分类
医药卫生引用本文复制引用
赵森泉,毛新润..跑台运动干预膝关节软骨全层缺损修复[J].中国组织工程研究,2017,21(16):2478-2483,6.基金项目
2016河北省医学科学研究重点课题计划项目(20160122) Funding:the Key Medical Research Program of Hebei Province in 2016, No. 20160122 （20160122）
