中国组织工程研究2017，Vol.21Issue(16)：2489-2494,6.DOI:10.3969/j.issn.2095-4344.2017.16.006
右美托咪啶可减轻骨科止血带所致缺血再灌注诱发的氧化应激和炎性损伤
Dexmedetomidine relieves oxidative stress and inflammatory damage after tourniquet-induced ischemia/reperfusion injury
摘要
Abstract
BACKGROUND: Dexmedetomidine has been shown to fight against ischemia/reperfusion injury induced by tourniquets. OBJECTIVE: To study the effects of dexmedetomidine on the oxidative stress and inflammatory damage caused by tourniquet-induced ischemia/reperfusion injury. METHODS: Seventy-six patients scheduled for lower limb operation were randomized into two groups: patients in dexmedetomidine group were given the intravenous injection of 1 μg/kg dexmedetomidine for 10 minutes, followed by 0.5 μg/kg?h until the end of operation; while the controls were subjected to 0.9% saline injection at an equivalent velocity and volume. The levels of serum propanediol, lactic dehydrogenase, superoxyde dismutase, tumor necrosis factor-α, interleukin-6 and -8 were detected before tourniquet inflation, 10, 60 and 120 minutes after tourniquet release. RESULTS AND CONCLUSION: In both two groups, the serum levels of propanediol, lactic dehydrogenase, tumor necrosis factor-α, interleukin-6 and -8 after tourniquet release were significantly higher and the serum superoxide dismutase level was significantly lower than those before tourniquet inflation (P < 0.05). Compared with the control group, dexmedetomidine significantly reduced the serum levels of propanediol, lactic dehydrogenase, tumor necrosis factor-α, interleukin-6 and -8, and increased the serum superoxyde dismutase level after tourniquet release (P < 0.05). These results suggest that dexmedetomidine can attenuate the oxidative stress and inflammatory damage resulting from tourniquet-induced ischemia/reperfusion injury probably by up-regulating the serum superoxyde dismutase level, and down-regulating the serum levels of propanediol, lactic dehydrogenase, tumor necrosis factor-α, interleukin-6 and -8.关键词
组织构建/组织工程/右美托咪啶/止血带/缺血再灌注/氧化应激/炎性损伤/江苏省自然科学基金分类
医药卫生引用本文复制引用
沈鹏飞,王斌,谢子康,郑冲,瞿玉兴..右美托咪啶可减轻骨科止血带所致缺血再灌注诱发的氧化应激和炎性损伤[J].中国组织工程研究,2017,21(16):2489-2494,6.基金项目
江苏省自然科学基金项目(BK20131485) （BK20131485）
常州市科技计划项目(CJ20141205) Funding:the Natural Science Foundation of Jiangsu Province, No. BK20131485 （CJ20141205）
the Science and Technology Program of Changzhou, No. CJ20141205 （）
