中国组织工程研究2017，Vol.21Issue(16)：2593-2599,7.DOI:10.3969/j.issn.2095-4344.2017.16.023
供、受者性别因素对公民逝世器官捐献供肾移植后肾功能恢复的影响
Effect of donor and recipient gender on the recovery of renal function after donation after cardiac death renal transplantation
摘要
Abstract
BACKGROUND: Donation after cardiac death (DCD) is becoming the main source of organs for transplantation. Donor and recipient gender may play an important role in preoperative evaluation and recipient selection of transplantation. OBJECTIVE: To analyze the effect of donor and recipient gender on the recovery of renal function after DCD renal transplantation, and to further guide the selection of recipients. METHODS: The clinical data of recipients and donors of DCD kidney transplantation performed at the First Affiliated Hospital of Zhengzhou University from July 2012 to March 2015 were analyzed retrospectively. According to donor and recipient gender, the donors and recipients were divided into four groups: group A (male donor, male recipient), group B (male donor, female recipient), group C (female donor, male recipient), group D (female donor, female recipient). The renal function of the recipients was recorded at 1 and 2 weeks, 1, 3, 6, and 12 months postoperatively to compare the effect of donor and recipient gender on the recovery of renal function. RESULTS AND CONCLUSION: The serum creatinine level in the groups A and B was lower than that in the groups C and D at postoperative different time points, and there was a significant difference at 3, 6 and 12 months postoperatively (P < 0.05). The estimated glomerular filtration rate in the groups A and B was significantly higher than that in the groups C and D at postoperative different time points (P < 0.05). The serum creatinine level in the group C was significantly higher than that in the other three groups at postoperative different time points (P < 0.05). The serum creatinine level in the group A was significantly higher than that in the group B at 3, 6 and 12 months postoperatively (P < 0.05). The glomerular filtration rate in the group A was significantly higher than that in the group C at postoperative different time points (P < 0.05). The glomerular filtration rate in the group B was significantly higher than that in the group D at 12 months postoperatively (P < 0.05). These results suggest that the male donors show superior renal function to the female donors. The postoperative recovery of renal function is relatively slow when the male recipients receive a kidney of female donors. The female recipients with lower body surface area who receive the kidney of elderly male donors with poor renal function can achieve favorable clinical effects. Therefore, the gender should be used as a reference index for selecting potential recipients.关键词
组织构建/组织工程/性别/公民逝世器官捐献/肾移植/肾功能恢复/受者选择/边缘性供肾/体表面积/国家自然科学基金分类
医药卫生引用本文复制引用
李金锋,孙佳佳,丰贵文,尚文俊,庞新路,刘磊,谢红昌,丰永花,王志刚..供、受者性别因素对公民逝世器官捐献供肾移植后肾功能恢复的影响[J].中国组织工程研究,2017,21(16):2593-2599,7.基金项目
国家自然科学基金(U1204820) （U1204820）
郑州大学第一附属医院青年基金(2011-QN010) Funding: the National Natural Science Foundation of China, No. U1204820 （2011-QN010）
the Foundation for the Youth of the First Affiliated Hospital of Zhengzhou University, No.2011-QN010 （）
