中国组织工程研究2017，Vol.21Issue(16)：2600-2605,6.DOI:10.3969/j.issn.2095-4344.2017.16.024
组织工程化皮肤:从形态和功能安全替代的前景
Tissue-engineered skin substitutes: a prospect evaluation from the aspects of morphology and function
摘要
Abstract
BACKGROUND: Tissue engineering is a booming subject in recent years, involving skin, cornea, bone, cartilage, tendon and etc. Noticeably, tissue-engineered skin is an issue of concern, which provides an alluring prospect for the repair of skin defects. OBJECTIVE: To overview the latest research progress of tissue-engineered skin. METHODS: A computer-based research of Medline database from 1996 to 2017 was performed, with the English keywords of "epidermis, dermis, tissue engineered skin". The latest research status of tissue-engineered skin was summarized in views of epidermal and dermal substitutes, followed by exploring the problems and prospects of tissue-engineered skin. RESULTS AND CONCLUSION: A total of 65 literatures were included. Complex skin substitutes include epidermis and dermis, in which hair follicles, sweat glands, sebaceous glands and other cutaneous appendages are absent. Therefore, how to solve above problems is a hotspot issue and major trend in tissue-engineered skin. Tissue-engineered skin aims to construct permanent skin substitutes containing melanocytes and Langerhans cells rapidly. Since the current tissue-engineered skin substitutes can completely replace skin tissues neither in morphology nor in function, in-depth studies are expected in the near future.关键词
组织构建/组织工程/皮肤黏膜组织构建/皮肤/表皮替代物/真皮替代物/组织工程/黑色素细胞/朗格罕氏细胞/国家自然科学基金分类
医药卫生引用本文复制引用
王晓静,王国伟,惠光艳,赵铱民..组织工程化皮肤:从形态和功能安全替代的前景[J].中国组织工程研究,2017,21(16):2600-2605,6.基金项目
国家自然科学基金(81271104) Funding: the National Natural Science Foundation of China, No. 81271104 （81271104）
