中国组织工程研究2017，Vol.21Issue(16)：2606-2611,6.DOI:10.3969/j.issn.2095-4344.2017.16.025
组织工程窦房结构建及血管化的最新研究与应用进展
Construction and vascularization of tissue-engineered sinus node in cardiac tissue engineering
摘要
Abstract
BACKGROUND: As in theory tissue-engineered sinus node can establish a new pacemaker in vivo when implanted into the human body, it is a promising treatment for sick sinus syndrome. But this method is immature and needs to be explored in depth. OBJECTIVE: To overview the different construction methods of tissue-engineered sinus node, and the research progress of vascularization in cardiac tissue engineering. METHODS: A computer-based retrieval in PubMed and CNKI databases was performed by the first author to search related papers published from 1984 to 2016 using the keywords of "vascularize, tissue engineering, sinus node" in English and Chinese, respectively. We summarized the construction methods of tissue-engineered sinus node and importance of vascularization in cardiac tissue engineering. RESULTS AND CONCLUSION: Sinus node cells, bone marrow mesenchymal stem cells, adipose-derived mesenchymal stem cells and embryonic stem cells can be used as seed cells. There are a variety of materials used for constructing tissue-engineered scaffolds, among which, collagen is the best choice. Three-dimensional printing technology and cell-sheet techbology make it possible to construct and transplant tissue-engineered sinus node. The early blood supply is the key for the successful sinus node transplantation. However, the vascularized tissue-engineered sinus node has not yet been reported. Endothelial progenitor cells can promote angiogenesis, but further explorations are warranted as there are some existing defects.关键词
组织构建/组织工程/器官移植/生物起搏/种子细胞/3D打印/细胞膜片技术/内皮祖细胞/缓释支架/国家自然科学基金分类
医药卫生引用本文复制引用
童灵犀,张传森,黄飞..组织工程窦房结构建及血管化的最新研究与应用进展[J].中国组织工程研究,2017,21(16):2606-2611,6.基金项目
国家自然科学基金(81071603,30970737) （81071603,30970737）
上海市自然科学重点基金(09JC1417700) Funding:the National Natural Science Foundation of China, No. 81071603, 30970737 （09JC1417700）
the Natural Science Foundation of Shanghai, No. 09JC1417700 （）
