中国组织工程研究2017，Vol.21Issue(17)：2741-2745,5.DOI:10.3969/j.issn.2095-4344.2017.17.019
干细胞转录因子OCT4、SOX2在食管鳞癌组织中表达及与预后的关系
Expression of OCT4 and SOX2 in esophageal squamous cell carcinoma and its relationship with clinical prognosis
温子海 1吕巧云 1李晓华1
作者信息
- 1. 唐山市工人医院集团丰南区医院外三科,河北省唐山市 063300
- 折叠
摘要
Abstract
BACKGROUND: Studies have shown that OCT4, SOX2 and HIWI can express in tumor tissues. OBJECTIVE: To investigate the relationship between the expression of stem cell transcription factors SOX2 and OCT4 in esophageal squamous cell carcinoma and their clinical characteristics and prognosis. METHODS: Expression levels of SOX2 and Oct4 were detected using immunohistochemical SP method in 77 cases of esophageal squamous cell carcinoma and 40 cases of adjacent cancer tissues confirmed by pathological examination, and then the their relationship with prognosis and clinical characteristics of the patients was analyzed. RESULTS AND CONCLUSION: Significantly higher levels of SOX2 and Oct4 were found in the esophageal cancer tissues than the adjacent cancer tissues (P < 0.05). SOX2 and Oct4 were highly expressed in the esophageal cancer tissues isolated from poorly differentiated, lymph node metastasis patients (P < 0.05). During the 2-year follow-up, the median survival of patients positive for SOX2 and Oct4 was only 24 and 21 months, respectively, which was significantly lower than that of negative patients (30 and 33 months, respectively). These findings indicate that the highly expressed SOX2 and Oct4 in esophageal cancer tissues are associated with the differentiation, metastasis and prognosis of the patients with esophageal squamous cell carcinoma.关键词
干细胞/肿瘤干细胞/食管鳞癌/Sry相关HMG盒2/八聚体结合转录因子4/临床特征/预后分类
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温子海,吕巧云,李晓华..干细胞转录因子OCT4、SOX2在食管鳞癌组织中表达及与预后的关系[J].中国组织工程研究,2017,21(17):2741-2745,5.
