眼科新进展2017，Vol.37Issue(6)：539-543,5.DOI:10.13389/j.cnki.rao.2017.0136
雷珠单抗预防伴有虹膜新生血管的糖尿病视网膜病变术后再出血疗效观察
Lucentis preventing vitreous hemorrhage after vitrectomy for diabetic retinopathy combined with iris neovascularization
摘要
Abstract
Objective To study the effects of lucentis preventing vitreous hemorrhage after vitrectomy for diabetic retinopathy combined with iris neovascularization.Methods The clinical data of 70 patients (70 eyes) underwent vitrectomy for diabetic retinopathy combined with iris neovascularization during 2009 to 2015 in our hospital were retrospectively analyzed.The control group (30 eyes) accepted panretinal photocoagulation (PRP),re-vitrectomy,cyclocryotherapy,and the study group (40 eyes) had the 0.5mg lucentis in addition.The follow-up time was 3 months,and the visual acuity,IOP,vitreous hemorrhage,INV regression and complication were observed.Results At 1 month,2 months in the follow-up,the visual acuity of study group was better than the control group,but there was no significant difference along with the follow up.The average preoperative IOP was (26.312 ±4.566) mmHg (1 kPa =7.5 mmHg) in the study group and (24.586 ±5.783) mmHg in the control group,and at the end of the follow up,IOP was (18.576 ±4.762) mmHg in the study group and (28.587 ±7.786) mmHg in the control group,there was statistical difference between the two groups (P =0.041).The intraoperative and postoperative anterior chamber or vitreous hemorrhage occurred in 15 cases,5 cases of the control group,and 3 cases,1 case of the control group,there were significant differences (all P =0.000).At the end of the follow up,3 eyes (7.5％) developed to NVG in the study group and 10 eyes (33.3％) in the control group,there was statistical difference (P ＜ 0.05).Conclusion Lucentis can effectively eliminate the new vessels,reduce the incidence of neovascularization glaucoma and vitreous hemorrhage for patients after vitrectomy for diabetic retinopathy combined with iris neovascularization,and improve the visual acuity in a short time.关键词
虹膜新生血管/雷珠单抗/糖尿病视网膜病变/视网膜激光光凝Key words
iris neovascularization/lucentis/diabetic retinopathy/retinal photocoagulation分类
医药卫生引用本文复制引用
毛子清,游志鹏,周五剑,罗文彬,李佳,吴超..雷珠单抗预防伴有虹膜新生血管的糖尿病视网膜病变术后再出血疗效观察[J].眼科新进展,2017,37(6):539-543,5.基金项目
国家自然科学基金资助(编号:81460088) （编号:81460088）
National Natural Science Foundation of China (No:81460088) （No:81460088）
